Brooks D P, Share L, Crofton J, Matsui K, Rockhold R W
Neuroendocrinology. 1984 Oct;39(4):350-5. doi: 10.1159/000124003.
The cardiovascular and vasopressin-releasing effects of vertebral artery, carotid artery and intravenous (i.v.) infusions of lysine vasopressin (150 microU/kg X min) were studied in anesthetized dogs. Vertebral and carotid artery infusions of lysine vasopressin led to similar decreases in cardiac output as i.v. infusions. Heart rate, however, decreased to a greater extent with vertebral and carotid artery infusions of lysine vasopressin than i.v. infusions. There were no changes in either mean arterial blood pressure or the plasma vasopressin concentration. The results indicate that peripheral vasopressin: has a central effect to reduce heart rate; has a peripheral effect on the heart to reduce cardiac output, and probably does not feed back to inhibit its own release.
在麻醉犬中研究了椎动脉、颈动脉输注赖氨酸加压素（150微单位/千克×分钟）以及静脉输注赖氨酸加压素对心血管和加压素释放的影响。椎动脉和颈动脉输注赖氨酸加压素导致的心输出量降低程度与静脉输注相似。然而，椎动脉和颈动脉输注赖氨酸加压素时心率的降低程度大于静脉输注。平均动脉血压和血浆加压素浓度均无变化。结果表明，外周加压素：具有降低心率的中枢作用；对心脏具有降低心输出量的外周作用，并且可能不会反馈抑制其自身释放。
