甲状腺激素对红细胞2,3 - 二磷酸甘油酸合成的作用机制。
Mechanism of action of thyroid hormones on erythrocyte 2,3-diphosphoglyceric acid synthesis.
作者信息
Snyder L M, Reddy W J
出版信息
J Clin Invest. 1970 Nov;49(11):1993-8. doi: 10.1172/JCI106419.
Abstract
Normal erythrocytes, when incubated with thyroid hormone, were found to have increased levels of 2,3-diphosphoglyceric acid. In addition, a partially purified enzyme preparation, when incubated with either a 1,3-diphosphoglyceric acid generating system or 1,3-diphosphoglyceric acid directly, showed increased levels of 2,3-diphosphoglyceric acid when exposed to thyroid hormone. The hormonal effect was biphasic and was witnessed after 5 min of incubation. Substitution on the 3 and 5 positions of the basic thyronine molecule was essential for hormonal effect. It appears that thyroid hormone acts by directly stimulating the diphosphoglycerate mutase enzyme. The hormonal effect on 2,3-DPG synthesis may offer a biochemical explanation for the shift in the oxyhemoglobin dissociation curve observed in thyroid disorders.
摘要
正常红细胞在与甲状腺激素一起孵育时，发现其二磷酸甘油酸水平升高。此外，一种部分纯化的酶制剂，当与1,3 - 二磷酸甘油酸生成系统或直接与1,3 - 二磷酸甘油酸一起孵育时，在暴露于甲状腺激素时显示其二磷酸甘油酸水平升高。激素效应是双相的，在孵育5分钟后即可观察到。甲状腺素分子3位和5位的取代对于激素效应至关重要。看来甲状腺激素通过直接刺激二磷酸甘油酸变位酶起作用。激素对2,3 - DPG合成的影响可能为甲状腺疾病中观察到的氧合血红蛋白解离曲线的变化提供生化解释。
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