1,25 - 二羟胆钙化醇及1,25 - 二羟胆钙化醇糖苷对大鼠红细胞2,3 - 二磷酸甘油酸水平的影响
Effect of 1,25-dihydroxycholecalciferol and 1,25-dihydroxycholecalciferol glycoside on 2,3-diphosphoglycerate levels of the rat erythrocyte.
作者信息
Skliar M I, Fernandez M C, Faienza H, Orsatti M B, Puche R C, Boland R L, Skliar M I
出版信息
Pflugers Arch. 1980 Dec;389(1):81-3. doi: 10.1007/BF00587932.
The erythrocytes of rats treated with 1, 25-dihydroxycholecalciferol or 1, 25-dihydroxycholecalciferol glycoside showed decreased levels of 2, 3-diphosphoglycerate. The same result has been obtained in vitro, indicating a direct effect of the sterol on the red cell. The glycoside is less active than the free sterol in vivo and more active in vitro. The decreased levels of diphosphoglycerate induced tissue hypoxia as shown by a higher plasma lactate/pyruvate ratio and a three fold increase in plasma erythropoietin concentration.
用1,25 - 二羟胆钙化醇或1,25 - 二羟胆钙化醇糖苷处理的大鼠红细胞显示2,3 - 二磷酸甘油酸水平降低。在体外也得到了相同的结果，表明该甾醇对红细胞有直接作用。该糖苷在体内的活性低于游离甾醇，而在体外更具活性。二磷酸甘油酸水平降低导致组织缺氧，表现为血浆乳酸/丙酮酸比值升高以及血浆促红细胞生成素浓度增加三倍。
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