Cozanitis D A, Dundee J W, Mirakhur R K
Acta Anaesthesiol Belg. 1979;30 Suppl:151-7.
Intermittent doses of suxamethonium have been known to result in bradycardia changes in cardiac rhythm. In order to assess the efficacy of a newer quaternary ammonium antimuscarinic, glycopyrrolate, on the cardia effects of intermittent suxamethonium, 28 patients received this drug intravenously just before induction of anesthesia. For comparison, 28 other patients were given atropine. In the atropine series, three patients developed bradycardia while none of those of the glycopyrrolate series did so. In addition, more patients had cardiac arrhythmias in the atropine group. Although no statistically significant differences were seen, clinically, glycopyrrolate seems to afford better protection against the cardiac changes resulting from intermittently administered suxamethonium.
已知间歇性给予琥珀酰胆碱会导致心动过缓和心律变化。为了评估一种新型季铵类抗毒蕈碱药物格隆溴铵对间歇性给予琥珀酰胆碱的心脏效应的疗效，28例患者在麻醉诱导前静脉注射了这种药物。作为对照，另外28例患者给予了阿托品。在阿托品组中，有3例患者出现心动过缓，而格隆溴铵组中无1例出现。此外，阿托品组有更多患者出现心律失常。尽管未观察到统计学上的显著差异，但从临床来看，格隆溴铵似乎能更好地预防间歇性给予琥珀酰胆碱所导致的心脏变化。
