孕期服用磺脲类药物的糖尿病母亲所生婴儿的新生儿低血糖症。
Neonatal hypoglycaemia in infants of diabetic mothers given sulphonylurea drugs in pregnancy.
作者信息
Kemball M L, McIver C, Milner R D, Nourse C H, Schiff D, Tiernan J R
出版信息
Arch Dis Child. 1970 Oct;45(243):696-701. doi: 10.1136/adc.45.243.696.
Abstract
Three infants whose diabetic mothers were given chlorpropamide and one infant whose diabetic mother was given acetohexamide up to the time of delivery were studied in the neonatal period because each became severely hypoglycaemic. The sulphonylurea drugs given to the mother crossed the placenta, and fetal plasma concentrations were in the therapeutic range for adults with diabetes mellitus. Each baby had severe hyperinsulinaemia resulting in profound hypoglycaemia. These acutely ill infants needed vigorous and prolonged treatment to correct the hypoglycaemia. In two infants exchange transfusion was performed to remove the drug. These sulphonylurea drugs should not be used to control diabetes mellitus in pregnancy.
摘要
三名患有糖尿病的母亲在分娩前服用了氯磺丙脲，一名患有糖尿病的母亲在分娩前服用了醋磺己脲，这四名婴儿在新生儿期接受了研究，因为他们均出现了严重低血糖。母亲服用的磺脲类药物穿过了胎盘，胎儿血浆浓度处于成年糖尿病患者的治疗范围内。每个婴儿都有严重的高胰岛素血症，导致严重低血糖。这些重病婴儿需要积极且长期的治疗来纠正低血糖。两名婴儿进行了换血以清除药物。这些磺脲类药物不应被用于控制妊娠期糖尿病。
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Neonatal hypoglycaemia in infants of diabetic mothers given sulphonylurea drugs in pregnancy.孕期服用磺脲类药物的糖尿病母亲所生婴儿的新生儿低血糖症。
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