Bowser-Riley S, Bain A D, Noble J, Lamb D W
Lancet. 1975 Dec 27;2(7948):1282-3. doi: 10.1016/s0140-6736(75)90614-5.
Palmar fascia from six men with Dupuytren's contracture has been grown in tissue-culture and examined cytogenetically; and in three of these cases skin was also studied. Four of the six cases showed mosaicism, but only in cultures of the fascia; the mosaicism was therefore unlikely to be an artefact. Since the abnormalities were inconsistent and absent from skin-cultures they are very unlikely to indicate any mechanism of inheritance. Similar chromosome abnormalities have been reported from experimentally induced tumours.
