Bonnici A V, Birjandi F, Spencer J D, Fox S P, Berry A C
Department of Orthopaedics, Guy's Hospital, London.
J Hand Surg Br. 1992 Jun;17(3):349-55. doi: 10.1016/0266-7681(92)90128-o.
The cytogenetics of cell cultures derived from Dupuytren's tissue, adjacent palmar fascia and palmar skin from patients undergoing fasciectomy have been examined and the results compared to cell cultures established from palmar fascia, flexor retinaculum and palmar skin of patients undergoing carpal tunnel decompression. Chromosomal abnormalities were detected in cell cultures from Dupuytren's tissue in eight of the nine patients studied. Clones of cells trisomic for chromosome 8 were found in five of the nine patients. Trisomy 8 was also present in two of five flexor retinaculum cultures from carpal tunnel syndrome cases. These findings in both Dupuytren's contracture and carpal tunnel syndrome suggest the presence of chromosomal instability in the palmar fascia. The significance of the chromosomal abnormalities is however unclear, but they indicate a possible common pathway in the onset of pathological fibrosis.
对接受筋膜切除术患者的掌腱膜组织、相邻掌腱膜及掌部皮肤来源的细胞培养物进行了细胞遗传学检查，并将结果与接受腕管减压术患者的掌腱膜、屈肌支持带及掌部皮肤建立的细胞培养物进行了比较。在所研究的9例患者中，9例掌腱膜组织细胞培养物检测到染色体异常。9例患者中有5例发现8号染色体三体细胞克隆。5例腕管综合征屈肌支持带培养物中也有2例存在8号染色体三体。掌腱膜挛缩症和腕管综合征的这些发现提示掌腱膜存在染色体不稳定性。然而，染色体异常的意义尚不清楚，但它们提示了病理性纤维化发病过程中可能存在的共同途径。
