Scadding J G
Postgrad Med J. 1970 Aug;46(538):465-7. doi: 10.1136/pgmj.46.538.465.
The concept of sarcoidosis as a systemic disease arose from the recognition that certain clinical phenomena which were at first described as ‘diseases’ affecting a number of different organs and tissues had in common (i) a histological pattern which can be described in general terms as a non-caseating tuberculoid granuloma and (ii) possible concurrence in the same patient in various combinations. These two features constitute the basis for a workable definition: Sarcoidosis is a disease characterized by the presence in all of several affected organs or tissues of epithelioid cell tubercles, without caseation though some fibrinoid necrosis may be present at the centres of a few tubercles, proceeding either to resolution or to hyaline fibrosis. Because knowledge of the causation of sarcoidosis is fragmentary, investigators must be left free to examine every possible aetiological hypothesis. For this reason, the definition should contain no reference to aetiology.
结节病作为一种全身性疾病的概念源于人们认识到，某些最初被描述为影响多个不同器官和组织的“疾病”具有以下共同特征：（i）一种组织学模式，一般可描述为非干酪样结核样肉芽肿；（ii）在同一患者身上可能以各种组合同时出现。这两个特征构成了一个可行定义的基础：结节病是一种疾病，其特征是在多个受影响的器官或组织中均存在上皮样细胞结节，无干酪样变，尽管少数结节中心可能存在一些纤维蛋白样坏死，病变可自行消退或发展为透明纤维化。由于结节病病因的知识尚不完整，研究人员必须能够自由地检验每一种可能的病因假说。因此，该定义不应提及病因。
