Israel H L, Goldstein R A
Postgrad Med J. 1970 Aug;46(538):468-70. doi: 10.1136/pgmj.46.538.468.
A prospective study of total and ultrafiltrable serum calcium levels in 121 patients with sarcoidosis and thirty-eight control subjects revealed no significant differences. Two patients had hypercalcaemia (11·6 and 12·2 mg%) at the time of initial sampling; one spontaneously returned to normal. Retrospective analysis of 318 cases previously studied demonstrated persistent hypercalcaemia in eight of 262 negroes and two of fifty-six whites, with a male to female ratio of seven to three. Serial calcium measurements in thirty-four patients and single determinations in eighty-seven patients taken during the course of 1 year failed to show seasonal fluctuation. These observations suggest that calcium metabolism is normal in most patients with sarcoidosis. When persistent hypercalcaemia is found in a patient with sarcoidosis, careful study for associated hyperparathyroidism is essential, especially if the sarcoidosis is otherwise asymptomatic or inactive.
一项针对121例结节病患者和38名对照者的血清总钙和超滤钙水平的前瞻性研究显示，二者无显著差异。两名患者在初次采样时出现高钙血症（分别为11.6和12.2mg%），其中一名患者血钙自发恢复正常。对之前研究的318例病例进行回顾性分析发现，262名黑人中有8名、56名白人中有2名持续存在高钙血症，男女比例为7:3。在1年的病程中，对34例患者进行了连续血钙测量，对87例患者进行了单次血钙测定，均未显示出季节性波动。这些观察结果表明，大多数结节病患者的钙代谢正常。当结节病患者出现持续性高钙血症时，必须仔细检查是否伴有甲状旁腺功能亢进，尤其是当结节病无症状或处于静止期时。
