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结节病累及肾脏。

Sarcoidosis with renal involvement.

作者信息

MacSearraigh E T, Doyle C T, Twomey M, O'Sullivan D J

出版信息

Postgrad Med J. 1978 Aug;54(634):528-32. doi: 10.1136/pgmj.54.634.528.

DOI:10.1136/pgmj.54.634.528
PMID:733683
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2425297/
Abstract

Nine of ninety patients with sarcoidosis were found to have significant renal impairment. Epithelioid granulomata were present in five of eight patients who had renal biopsies and glomerular lesions were present in six. There was close correlation between hypercalcaemia, hyperuricaemia, nephrocalcinosis and creatinine clearance. In one patient, renal sarcoidosis complicated membrano-proliferative glomerulonephritis and one patient died in end-stage renal disease.

摘要

90例结节病患者中有9例被发现存在明显的肾功能损害。在接受肾活检的8例患者中，有5例存在上皮样肉芽肿，6例存在肾小球病变。高钙血症、高尿酸血症、肾钙质沉着症与肌酐清除率之间存在密切相关性。1例患者的肾结节病并发膜增生性肾小球肾炎，1例患者死于终末期肾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b806/2425297/655657326463/postmedj00260-0028-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b806/2425297/eb020cd9fcb8/postmedj00260-0026-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b806/2425297/6136f6dd130c/postmedj00260-0027-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b806/2425297/655657326463/postmedj00260-0028-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b806/2425297/eb020cd9fcb8/postmedj00260-0026-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b806/2425297/6136f6dd130c/postmedj00260-0027-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b806/2425297/655657326463/postmedj00260-0028-a.jpg

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2
A case of systemic sarcoidosis with mesangial proliferative glomerulonephritis showing predominant deposition of IgG in the mesangial region.全身性肉样瘤病合并系膜增生性肾小球肾炎，免疫球蛋白 G 在系膜区呈优势沉积。
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Diagnosis and Detection of Sarcoidosis. An Official American Thoracic Society Clinical Practice Guideline.

本文引用的文献

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Glomerular lesions of the kidneys in sarcoidosis (Boeck's sarcoid).结节病（伯克氏结节病）时肾脏的肾小球病变
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Renal involvement in sarcoidosis.结节病的肾脏受累情况。
Postgrad Med J. 1970 Aug;46(538):526-9. doi: 10.1136/pgmj.46.538.526.
结节病的诊断与检测：美国胸科学会临床实践指南
Am J Respir Crit Care Med. 2020 Apr 15;201(8):e26-e51. doi: 10.1164/rccm.202002-0251ST.
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Systemic Sarcoidosis Presenting with Renal Involvement Caused by Various Sarcoidosis-associated Pathophysiological Conditions.系统性结节病伴肾脏受累，由多种结节病相关病理生理状况引起
Intern Med. 2019 Mar 1;58(5):679-684. doi: 10.2169/internalmedicine.1558-18. Epub 2018 Nov 19.
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Acute kidney injury caused by sarcoid granulomatous interstitial nephritis without extrarenal manifestations.由结节病肉芽肿性间质性肾炎引起的急性肾损伤，无肾外表现。
CEN Case Rep. 2015 Nov;4(2):212-217. doi: 10.1007/s13730-015-0171-4. Epub 2015 Mar 5.
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IgM-immune complex glomerulonephritis associated with sarcoidosis.与结节病相关的IgM免疫复合物肾小球肾炎。
Clin Exp Nephrol. 2006 Mar;10(1):68-73. doi: 10.1007/s10157-005-0390-7.
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Fatal renal failure as the first manifestation of sarcoidosis diagnosed on necropsy in a young man: a case report.一名年轻男性尸检诊断结节病以致命性肾衰竭为首发表现：病例报告
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Sarcoidosis and membranous glomerulonephritis: a significant association.结节病与膜性肾小球肾炎：一种显著关联。
Br Med J (Clin Res Ed). 1982 May 1;284(6325):1297-8. doi: 10.1136/bmj.284.6325.1297.
10
Glomerulonephritis in sarcoidosis: causal relationship unproven.结节病中的肾小球肾炎：因果关系未得到证实。
Postgrad Med J. 1992 Mar;68(797):206-8. doi: 10.1136/pgmj.68.797.206.
4
Frequency of disordered calcium metabolism in sarcoidosis.结节病中钙代谢紊乱的发生率。
Postgrad Med J. 1970 Aug;46(538):468-70. doi: 10.1136/pgmj.46.538.468.