静脉注射抗原对人体外周血中特异性抗原敏感淋巴细胞的影响。
The effect of antigen given intravenously on specific antigen-sensitive lymphocytes of peripheral blood in man.
作者信息
Kreth H W, Thiessen G, Deicher H
出版信息
Clin Exp Immunol. 1970 Jul;7(1):109-14.
In the course of fibrinolytic therapy with the streptococcal antigen the effect of antigen intravenously on specific antigen-sensitive lymphocytes in the peripheral blood was studied. Seven out of ten patients had streptokinase-sensitive lymphocytes in the peripheral blood before the beginning of therapy. Stimulation by streptokinase was temporarily rendered negative in all seven cases during the course of treatment. Some time after the termination of therapy specifically sensitive lymphocytes reappeared in the circulation. Lymphocytes of three patients were stimulated by streptokinase only after the treatment period. Stimulation of lymphocytes by phytohaemagglutinin or by tuberculin in sensitized individuals, was not disturbed. Thus streptokinase given intravenously involves selectively streptokinase-sensitive cells. It is assumed that after interaction with homologous antigen these lymphocytes are directed to lymphoid tissues where proliferation and differentiation takes place.
在用链球菌抗原进行纤维蛋白溶解疗法的过程中，研究了静脉注射抗原对外周血中特定抗原敏感淋巴细胞的影响。十名患者中有七名在治疗开始前外周血中有链激酶敏感淋巴细胞。在治疗过程中，所有七例患者中链激酶的刺激作用暂时变为阴性。治疗终止一段时间后，特异性敏感淋巴细胞重新出现在循环中。三名患者的淋巴细胞仅在治疗期后受到链激酶刺激。致敏个体中植物血凝素或结核菌素对淋巴细胞的刺激未受干扰。因此，静脉注射链激酶选择性地涉及链激酶敏感细胞。据推测，与同源抗原相互作用后，这些淋巴细胞被导向发生增殖和分化的淋巴组织。
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