Fernandez-Palazzi F, Bosch N B, Vargas A F
Int Orthop. 1979;3(2):159-64. doi: 10.1007/BF00266888.
Twenty joints in 19 haemophiliacs were treated by radioactive synoviorthesis with gold (Au 198) to prevent recurrent haemarthrosis. Twelve knees, six elbows and two ankles were treated in two separate groups (29. 9. 76 and 9. 5. 77). In eight cases (40%) no further haemarthrosis occurred. A diminution of bleeding was obtained in nine cases (45%), a total of 85% good results with 15% failures. One failure in the first group (an elbow) had a second synoviorthesis and was included in the second group also. Prior to synoviorthesis the joint was scanned with technetium (Tc99m) to compare the inflammation of the synovium with that of six months later. The technique including the dosage of Tc99m, Au 198, and factor VIII cover is presented. A leucocyte culture was performed in 16 cases to study any chromosomal breakage, by banding and fluorescent techniques.
对19名血友病患者的20个关节进行了放射性滑膜切除术，使用金（Au 198）以预防复发性关节积血。在两个不同的组（1976年9月29日和1977年5月9日）中，对12个膝关节、6个肘关节和2个踝关节进行了治疗。8例（40%）未再发生关节积血。9例（45%）出血减少，总有效率为85%，失败率为15%。第一组中的1例失败病例（一个肘关节）进行了第二次滑膜切除术，并也被纳入第二组。在滑膜切除术之前，用锝（Tc99m）对关节进行扫描，以比较滑膜炎症与六个月后的炎症情况。介绍了包括Tc99m、Au 198剂量和因子VIII覆盖的技术。对16例患者进行了白细胞培养，通过显带和荧光技术研究任何染色体断裂情况。
