Ahlberg A
Rev Rhum Mal Osteoartic. 1977 Jan;44(1):41-4.
Intra-articular haemorrhage in haemophiliacs often provokes chronic synovitis which leads to further repeated haemorrhages. This conditions has been treated by means of intra-articular injection of 198Au in colloidal solution and this treatment has cured the synovitis in 50 per cent of cases and given a notable improvement in about another 40 percent. Because of this, in this group of patients it was possible to reduce replacement therapy to less than 1/4 and the effect persisted over at least 3 years. This treatment even means that surgical synovectomy may be avoided in many cases. No unfavourable effects were seen on joint mobility or on bone growth but an undesirable effect of the radioactivity has been described in the form of chromosome changes in the circulating lymphocytes, and the importance of these pathological transformations is the subject of new experiments.
血友病患者的关节内出血常引发慢性滑膜炎，进而导致进一步的反复出血。这种情况已通过关节内注射胶体溶液中的198Au进行治疗，该治疗在50%的病例中治愈了滑膜炎，在另外约40%的病例中取得了显著改善。因此，在这组患者中，可以将替代疗法减少到不到四分之一，且效果至少持续3年。这种治疗甚至意味着在许多情况下可以避免手术滑膜切除术。未观察到对关节活动度或骨骼生长有不利影响，但已描述了放射性的不良影响，表现为循环淋巴细胞中的染色体变化，这些病理转变的重要性是新实验的主题。
