支配神经和去神经大鼠输精管对激动剂药物敏感性的比较。
A comparison of the sensitivities of innervated and denervated rat vasa deferentia to agonist drugs.
作者信息
Birmingham A T, Paterson G, Wójcicki J
出版信息
Br J Pharmacol. 1970 Aug;39(4):748-54. doi: 10.1111/j.1476-5381.1970.tb09901.x.
Abstract
- One vas deferens of a rat was denervated by stripping away the serous coat; the other vas was left intact as a control. One week later the sensitivity in vitro of both vasa deferentia to noradrenaline, adrenaline, dopamine, oxymetazoline or acetylcholine was measured.2. Log concentration response curves for the mean responses of both vasa from a group of four rats for each drug were plotted. Denervated vasa were more sensitive than control vasa to noradrenaline (16-fold), to adrenaline (8-fold), to dopamine (2-fold) and to oxymetazoline (2-fold). Denervated vasa were more sensitive to acetylcholine over the lower half of the concentration range only.3. It is concluded that these results support the theory that at least part of the increased sensitivity of denervated smooth muscle to catecholamines is due to an abolition or reduction of the neuronal uptake process. There is also a small non-specific increase in sensitivity.
摘要
通过剥去浆膜层使一只大鼠的一侧输精管去神经支配；另一侧输精管保持完整作为对照。一周后，测量两侧输精管对去甲肾上腺素、肾上腺素、多巴胺、羟甲唑啉或乙酰胆碱的体外敏感性。
绘制了一组四只大鼠的两侧输精管对每种药物的平均反应的对数浓度反应曲线。去神经支配的输精管对去甲肾上腺素（16倍）、肾上腺素（8倍）、多巴胺（2倍）和羟甲唑啉（2倍）的敏感性高于对照输精管。去神经支配的输精管仅在浓度范围的下半部分对乙酰胆碱更敏感。
得出的结论是，这些结果支持以下理论：去神经支配的平滑肌对儿茶酚胺敏感性增加至少部分是由于神经元摄取过程的消除或减少。敏感性也有小的非特异性增加。
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