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采用两级孕激素方法并具有相关治疗作用的口服避孕(作者译)

[Oral contraception with an associated therapeutic action using a progestational method at two levels (author's transl)].

作者信息

Soutoul J H, Renaud M

出版信息

J Gynecol Obstet Biol Reprod (Paris). 1979;8(6):561-5.

PMID:548557
Abstract

The authors, basing their work on their experience over many years with a large number of cases, are proposing that synthetic progestational agents can be used at two levels of dosage, to serve as contraception and as a treatment when a progestational agent is used and is followed by micro-dosages of another progestational substance. So they prescribe at the end a of cycle following different dosages for different lengths of time, the same (or a different) progestational agent to treat breast troubles or menstrual troubles which are often intricate, particularly near the menopause. The authors in this way can compare by trials the effects of this method as compared with those of a progestational contraceptive administered in high doses and prescribed in an interrupted way and the prescription of micro-dosages of progestational agents that are taken "non-stop" which is now a classical method of treatment. This new method of contraception using progestational agents at two levels of dosage is particularly useful in patients who cannot take oestrogens because of metabolic upsets or because of tumours and who have reacted badly to the two other methods mentioned. If the dose, which can be calculated thanks to our knowledge of the hormonal background of the patient, is altered good therapeutic results and a relatively sure method of contraception is evolved without metabolic risks for the patient. This association of two progestational levels of dosage seems to be indicated particularly in women of over 40 years of age.

摘要

基于多年来对大量病例的经验,作者们提出,合成孕激素制剂可在两种剂量水平上使用,一是用作避孕,二是在使用一种孕激素制剂后接着使用微剂量的另一种孕激素物质时用作治疗。因此,他们在周期结束时根据不同剂量规定不同的用药时长,使用相同(或不同)的孕激素制剂来治疗往往错综复杂的乳房问题或月经问题,尤其是在绝经前后。通过这种方式,作者们可以通过试验比较该方法与大剂量、间断服用的孕激素避孕药以及“不间断”服用微剂量孕激素制剂(这是目前一种经典的治疗方法)的效果。这种在两种剂量水平上使用孕激素制剂的新型避孕方法,对于因代谢紊乱或患有肿瘤而不能服用雌激素,且对上述另外两种方法反应不佳的患者尤为有用。如果根据我们对患者激素背景的了解来计算剂量,并进行调整,就能产生良好的治疗效果,同时形成一种相对可靠的避孕方法,且对患者没有代谢风险。这种两种剂量水平的孕激素联合使用似乎特别适用于40岁以上的女性。

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