抗生素和化疗药物在琼脂平板中的稳定性。
Stability of antibiotics and chemotherapeutics in agar plates.
作者信息
Ryan K J, Needham G M, Dunsmoor C L, Sherris J C
出版信息
Appl Microbiol. 1970 Sep;20(3):447-51. doi: 10.1128/am.20.3.447-451.1970.
The stability of chemotherapeutic agents incorporated into agar plates was studied by comparison of minimum inhibitory concentrations on fresh and stored plates and by direct bioassay of the chemotherapeutic agar plates. Plates were stored in sealed bags at 4 C. No loss of bioactivity was demonstrated after 30 days of storage in plates containing methicillin, erythromycin, cephalothin, tetracycline, chloramphenicol, kanamycin, streptomycin, polymyxin B, or nalidixic acid. Penicillin G, ampicillin, and nitrofurantoin showed statistically significant losses of activity after 4 weeks. None of the chemotherapeutics tested showed significant loss in activity after 1 week.
通过比较新鲜平板和储存平板上的最低抑菌浓度以及对化疗琼脂平板进行直接生物测定，研究了掺入琼脂平板中的化疗药物的稳定性。平板密封袋包装后于4℃保存。含甲氧西林、红霉素、头孢噻吩、四环素、氯霉素、卡那霉素、链霉素、多粘菌素B或萘啶酸的平板保存30天后未显示生物活性丧失。青霉素G、氨苄西林和呋喃妥因在4周后显示出具有统计学意义的活性丧失。所测试的化疗药物在1周后均未显示出明显的活性丧失。
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