受灭活药敏纸片影响的耐药性
Drug resistance as influenced by inactivated sensitivity discs.
作者信息
Griffith L J, Mullins C G
出版信息
Appl Microbiol. 1968 Apr;16(4):656-8. doi: 10.1128/am.16.4.656-658.1968.
Abstract
Reports of staphylococci resistant to the semisynthetic penicillins stimulated a study of the factors influencing the stability of the drugs in discs. The behavior of penicillin G, methicillin, oxacillin, cloxacillin, and cephalothin discs under different humidity and temperature conditions is described. Humidity was found to be the most significant factor in drug inactivation. Storage of discs in a vacuum desiccator at -20 C provides maximal antibiotic stability.
摘要
关于对半合成青霉素耐药的葡萄球菌的报告促使人们对影响药敏纸片中药物稳定性的因素展开研究。本文描述了青霉素G、甲氧西林、苯唑西林、氯唑西林和头孢噻吩药敏纸片在不同湿度和温度条件下的情况。结果发现，湿度是导致药物失活的最重要因素。将药敏纸片储存在-20℃的真空干燥器中可使抗生素稳定性达到最高。
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