接触终止数年后铅的排泄及其生物活性。
Excretion of lead and its biological activity several years after termination of exposure.
作者信息
Prerovská I, Teisinger J
出版信息
Br J Ind Med. 1970 Oct;27(4):352-5. doi: 10.1136/oem.27.4.352.
Abstract
352-355. A group of 27 persons who had been treated some years previously for chronic lead poisoning at our clinic, and who had not come into occupational contact with lead since, was examined. Half of them had had no occupational exposure to lead for 3 to 5 years and the others for 8 to 17 years. In most of these persons there is still an increased lead excretion, originating from an increased deposit in the bones. The mobilization test after calcium versenate (CaEDTA) injection was greater than 0·350 mg/24 hours. The values found for haemoglobin, punctate basophilia, coproporphyrin and ALA in urine were normal, but there was, in all cases, a decreased ALA-D activity. This finding suggests biological activity of such negligible lead flow many years after termination of exposure.
摘要
352 - 355. 对一组27人进行了检查，这些人几年前在我们诊所接受过慢性铅中毒治疗，此后未再接触职业性铅。其中一半人已有3至5年未接触职业性铅，另一半人则有8至17年未接触。在这些人中，大多数人仍有铅排泄增加的情况，这源于骨骼中铅沉积的增加。注射依地酸钙钠（CaEDTA）后的动员试验大于0·350毫克/24小时。尿液中血红蛋白、点彩嗜碱性粒细胞、粪卟啉和δ-氨基乙酰丙酸（ALA）的值均正常，但所有病例中δ-氨基乙酰丙酸脱水酶（ALA - D）活性均降低。这一发现表明，在接触终止多年后，如此微量的铅流仍具有生物活性。
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