Kramer P, Trautmann M, Heuer E, Drobnik L, Matthaei D, Gröne H J, Rieger J, Hölscher F, Langescheid C, Scheler F
Proc Eur Dial Transplant Assoc. 1979;16:205-11.
Haemofiltrate was administered into the duodenum of 5 ambulatory dogs through an implanted silastic catheter at a rate of 5-10 ml/min. None of the dogs presented signs of discomfort or suffered from regurgitation or diarrhoea. All 5 dogs had solid stools, enhanced diuresis and no change in body weight over a time period of 8 hours. Filtration rates between 5 and 10 ml/min were obtained in 7 dogs after connecting an Amicon in-line Ultrafilter with an external a.v. shunt. The intestinal recycling rate via the duodenal tube as a rule was 2 ml/min lower than the free flow ultrafiltration. Recirculation of autologous haemofiltrate in 5 uraemic dogs indicated unselective reabsorption of all electrolytes and small molecules. In 5 experiments with intestinal substitution of ultrafiltrate by a potassium-free Ringer's lactate solution, correction of acidosis and decrease in plasma potassium, creatinine and BUN was achieved.
通过植入的硅橡胶导管，以5 - 10毫升/分钟的速度将血液滤过液注入5只活动犬的十二指肠。没有一只犬出现不适迹象，也没有反流或腹泻。在8小时的时间段内，所有5只犬的粪便成形，利尿增强，体重无变化。在将Amicon在线超滤器与外部动静脉分流器连接后，7只犬的滤过率达到5至10毫升/分钟。通常通过十二指肠管的肠道再循环率比自由流动超滤低2毫升/分钟。5只尿毒症犬自体血液滤过液的再循环表明所有电解质和小分子均被非选择性重吸收。在5次用无钾乳酸林格液进行肠道超滤替代的实验中，实现了酸中毒的纠正以及血浆钾、肌酐和血尿素氮的降低。
