Sonkodi S, Joó F, Maurer M
Br J Exp Pathol. 1970 Oct;51(5):448-52.
The permeability state of the blood-brain barrier has been investigated in rats with renal hypertension. We have observed that the permeability of brain vessels is considerably increased both if, apart from the ischaemic kidney, the contralateral one was removed and also if we left it untouched. The plasma renin activity was only increased; compared with control animals however, in that form of hypertension where, besides the ischaemic kidney, the contralateral one remained untouched. We suppose that the change in plasma renin level does not play any essential role in the increased permeability of the blood-brain barrier.
我们研究了肾性高血压大鼠血脑屏障的通透性状态。我们观察到，除了缺血肾外，如果对侧肾被切除，或者对侧肾未处理，脑血管的通透性都会显著增加。血浆肾素活性仅在一种高血压形式中增加，即除了缺血肾外，对侧肾未处理的情况下，与对照动物相比。我们推测血浆肾素水平的变化在血脑屏障通透性增加中不起任何重要作用。
