Dolby A E
Clin Exp Immunol. 1970 Nov;7(5):681-6.
Preincubation with rabbit anti-human lymphocyte serum suppressed the cytotoxicity of peripheral blood lymphocytes from patients suffering from Mikulicz's recurrent oral aphthae for oral epithelial cells. Further studies revealed that although the anti-lymphocyte antibody remained bound to the lymphocytes after the pre-incubation procedure it exerted no demonstrable cytotoxic effect and induced a minimal degree of transformation. The mechanisms by which the anti-lymphocyte serum may have suppressed the lymphocytotoxicity are discussed.
用兔抗人淋巴细胞血清进行预孵育,可抑制米库利奇复发性口腔口疮患者外周血淋巴细胞对口腔上皮细胞的细胞毒性。进一步研究表明,尽管预孵育后抗淋巴细胞抗体仍与淋巴细胞结合,但它没有表现出明显的细胞毒性作用,且仅诱导了最低程度的转化。文中讨论了抗淋巴细胞血清可能抑制淋巴细胞毒性的机制。