对复发性口腔溃疡患者血液白细胞对口腔上皮细胞体外细胞毒性作用的效应细胞的特性分析。
Characterisation of the effector cells responsible for the in vitro cytotoxicity of blood leucocytes from aphthous ulcer patients for oral epithelial cells.
作者信息
Thomas D W, Bagg J, Walker D M
机构信息
Department of Oral Surgery, Medicine and Pathology, Dental School, University of Wales College of Medicine, Cardiff.
出版信息
Gut. 1990 Mar;31(3):294-9. doi: 10.1136/gut.31.3.294.
This study was designed to identify the cells responsible for the spontaneous cell mediated cytotoxic effect (SCMC) exerted by peripheral blood leucocytes from patients with recurrent aphthous ulceration, towards cultured oral epithelial cells. Peripheral blood leucocytes from recurrent aphthous ulceration patients exerted a significantly greater (p less than 0.01) degree of cytotoxicity towards the oral epithelial target cells than did peripheral blood leucocytes from healthy control subjects, or from patients with non-specific ulceration. Depletion of CD-5 positive cells (T-lymphocytes) resulted in a significant decrease in the SCMC in aphthous patients. Depletion of CD-16 positive cells (NK-cells) produced no significant change in cytotoxicity. T-lymphocytes, therefore, appear to be intimately involved in the in vitro SCMC effect in recurrent aphthous ulceration.
本研究旨在确定复发性阿弗他溃疡患者外周血白细胞对培养的口腔上皮细胞产生自发细胞介导细胞毒性作用（SCMC）的相关细胞。与健康对照受试者或非特异性溃疡患者的外周血白细胞相比，复发性阿弗他溃疡患者的外周血白细胞对口腔上皮靶细胞具有显著更强（p<0.01）的细胞毒性。去除CD-5阳性细胞（T淋巴细胞）导致阿弗他患者的SCMC显著降低。去除CD-16阳性细胞（NK细胞）对细胞毒性没有显著影响。因此，T淋巴细胞似乎密切参与了复发性阿弗他溃疡的体外SCMC效应。
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