复发性阿弗他溃疡。血清和外周血淋巴细胞对口腔上皮组织培养细胞的影响。
Recurrent aphthous ulceration. Effect of sera and peripheral blood lymphocytes upon oral epithelial tissue culture cells.
作者信息
Dolby A E
出版信息
Immunology. 1969 Nov;17(5):709-14.
In order to elucidate the possible role of humoral and cellular immune mechanisms in the pathogenesis of recurrent aphthous ulceration, a series of tissue culture experiments was undertaken in which oral epithelial cells were used as target cells. The survival of the oral epithelial cells was assessed, after culture for 24 hours, with the addition of sera, lymphocytes, or both sera and lymphocytes, from patients with recurrent aphthous ulceration and from persons free of the disease. In the experiments in which serum alone was added, there was no significant difference between the patients with recurrent aphthous ulceration and the controls. The addition of lymphocytes from patients suffering from recurrent aphthous ulceration, in either lymphocyte donor serum or inactivated foetal bovine serum, reduced significantly the level of survival of the oral epithelial cells as compared with the controls.
为了阐明体液免疫和细胞免疫机制在复发性阿弗他溃疡发病机制中可能发挥的作用，开展了一系列组织培养实验，其中将口腔上皮细胞用作靶细胞。在添加复发性阿弗他溃疡患者和无此病者的血清、淋巴细胞或血清与淋巴细胞二者之后，培养24小时，评估口腔上皮细胞的存活情况。在仅添加血清的实验中，复发性阿弗他溃疡患者与对照组之间无显著差异。与对照组相比，添加来自复发性阿弗他溃疡患者的淋巴细胞（无论是淋巴细胞供体血清还是灭活胎牛血清中），均显著降低了口腔上皮细胞的存活水平。
Zotero 插件