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亚麻籽氢过氧化物异构酶对亚油酸氢过氧化物的酶促转化。

The enzymic conversion of linoleic acid hydroperoxide by flax-seed hydroperoxide isomerase.

作者信息

Veldink G A, Vliegenthart J F, Boldingh J

出版信息

Biochem J. 1970 Nov;120(1):55-60. doi: 10.1042/bj1200055.

DOI:10.1042/bj1200055
PMID:5494229
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1179568/
Abstract
  1. The mode of action of flax-seed hydroperoxide isomerase was studied in vitro by using as substrates linoleic acid hydroperoxides formed by soya-bean lipoxygenase. 2. The enzyme converts only 13-hydroperoxyoctadeca-cis-9-trans-11-dienoic acid, whereas the 9-hydroperoxy isomer does not react. 3. The isomerization product was identified by chemical and spectroscopic methods as 13-hydroxy-12-oxo-octadec-cis-9-enoic acid. 4. 12,13-Epoxyoleic acid isomers do not act as intermediates in the isomerization reaction. 5. Suggestions for a functional relationship between hydroperoxide isomerase and lipoxygenase are discussed.
摘要
  1. 通过使用大豆脂氧合酶形成的亚油酸氢过氧化物作为底物，在体外研究了亚麻籽氢过氧化物异构酶的作用模式。2. 该酶仅能转化13-氢过氧十八碳-顺-9-反-11-二烯酸，而9-氢过氧异构体不发生反应。3. 通过化学和光谱方法将异构化产物鉴定为13-羟基-12-氧代-十八碳-顺-9-烯酸。4. 12,13-环氧油酸异构体在异构化反应中不作为中间体。5. 讨论了氢过氧化物异构酶与脂氧合酶之间功能关系的相关建议。

相似文献

1
The enzymic conversion of linoleic acid hydroperoxide by flax-seed hydroperoxide isomerase.亚麻籽氢过氧化物异构酶对亚油酸氢过氧化物的酶促转化。
Biochem J. 1970 Nov;120(1):55-60. doi: 10.1042/bj1200055.
2
Sequential enzymes of linoleic acid oxidation in corn germ: lipoxygenase and linoleate hydroperoxide isomerase.玉米胚芽中亚油酸氧化的顺序酶：脂氧合酶和亚油酸氢过氧化物异构酶。
J Lipid Res. 1970 Jul;11(4):311-21.
3
Positional specificity of gamma-ketol formation from linoleic acid hydroperoxides by a corn germ enzyme.玉米胚芽酶催化亚油酸氢过氧化物生成γ-酮醇的位置特异性
Lipids. 1975 Oct;10(10):602-8. doi: 10.1007/BF02532724.
4
The origin and structures of dimeric fatty acids from the anaerobic reaction between soya-bean lipoxygenase, linoleic acid and its hydroperoxide.大豆脂氧合酶、亚油酸及其氢过氧化物厌氧反应中二聚脂肪酸的起源与结构
Biochem J. 1972 Nov;130(2):435-42. doi: 10.1042/bj1300435.
5
Enzymic reactions of fatty acid hydroperoxides in extracts of potato tuber. I. Comparison 9D- and 13L-hydroperoxy-octadecadienoic acids as substrates for the formation of a divinyl ether derivative.马铃薯块茎提取物中脂肪酸氢过氧化物的酶促反应。I. 以9D-和13L-氢过氧十八碳二烯酸作为底物形成二乙烯基醚衍生物的比较
Biochim Biophys Acta. 1975 Jul 22;398(1):1-9.
6
The enzymic conversion of linoleic acid into 9-(nona-1',3'-dienoxy)non-8-enoic acid, a novel unsaturated ether derivative isolated from homogenates of Solanum tuberosum tubers.亚油酸向9-(壬-1',3'-二烯氧基)壬-8-烯酸的酶促转化，9-(壬-1',3'-二烯氧基)壬-8-烯酸是一种从马铃薯块茎匀浆中分离出的新型不饱和醚衍生物。
Biochem J. 1972 Sep;129(3):743-53. doi: 10.1042/bj1290743.
7
Substitution reactions of linoleic acid hydroperoxide isomerase.亚油酸氢过氧化物异构酶的取代反应
Lipids. 1975 Aug;10(8):448-53. doi: 10.1007/BF02532427.
8
The formation of cis-3-nonenal, trans-2-nonenal and hexanal from linoleic acid hydroperoxide isomers by a hydroperoxide cleavage enzyme system in cucumber (Cucumis sativus) fruits.黄瓜（Cucumis sativus）果实中的氢过氧化物裂解酶系统由亚油酸氢过氧化物异构体形成顺式-3-壬烯醛、反式-2-壬烯醛和己醛。
Biochim Biophys Acta. 1976 Aug 23;441(2):181-92. doi: 10.1016/0005-2760(76)90161-2.
9
Formation of alpha- and gamma-ketols from 18O-labelled linoleic acid hydroperoxides by corn germ hydroperoxide isomerase.玉米胚芽氢过氧化物异构酶催化18O标记的亚油酸氢过氧化物生成α-和γ-酮醇
FEBS Lett. 1976 Aug 15;67(2):149-52. doi: 10.1016/0014-5793(76)80353-5.
10
An anaerobic reaction between lipoxygenase, linoleic acid and its hydroperoxides.脂氧合酶、亚油酸及其氢过氧化物之间的厌氧反应。
Biochem J. 1971 Apr;122(3):327-32. doi: 10.1042/bj1220327.

引用本文的文献

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Dual positional substrate specificity of rice allene oxide synthase-1: insight into mechanism of inhibition by type II ligand imidazole.水稻丙二烯氧化物合酶-1 的双重位置底物特异性：对 II 型配体咪唑抑制机制的深入了解。
BMB Rep. 2013 Mar;46(3):151-6. doi: 10.5483/bmbrep.2013.46.3.117.
2
Intracellular distribution of hydroperoxide isomerase.过氧化氢异构酶的细胞内分布。
Plant Physiol. 1974 Jan;53(1):1-4. doi: 10.1104/pp.53.1.1.
3
Catalytic properties of allene oxide synthase from flaxseed (Linum usitatissimum L.).亚麻籽（亚麻）中丙二烯氧化物合酶的催化特性。
Lipids. 1998 Feb;33(2):191-6. doi: 10.1007/s11745-998-0195-9.
4
An anaerobic reaction between lipoxygenase, linoleic acid and its hydroperoxides.脂氧合酶、亚油酸及其氢过氧化物之间的厌氧反应。
Biochem J. 1971 Apr;122(3):327-32. doi: 10.1042/bj1220327.
5
Lipoxygenase from potato tubers. Partial purification and properties of an enzyme that specifically oxygenates the 9-position of linoleic acid.来自马铃薯块茎的脂氧合酶。一种特异性氧化亚油酸9位的酶的部分纯化及性质
Biochem J. 1971 Sep;124(2):431-8. doi: 10.1042/bj1240431.
6
The enzymic conversion of linoleic acid into 9-(nona-1',3'-dienoxy)non-8-enoic acid, a novel unsaturated ether derivative isolated from homogenates of Solanum tuberosum tubers.亚油酸向9-(壬-1',3'-二烯氧基)壬-8-烯酸的酶促转化，9-(壬-1',3'-二烯氧基)壬-8-烯酸是一种从马铃薯块茎匀浆中分离出的新型不饱和醚衍生物。
Biochem J. 1972 Sep;129(3):743-53. doi: 10.1042/bj1290743.
7
Analysis of lipoxygenase nonvolatile reaction products of linoleic acid in aqueous cereal suspensions by urea extraction and gas chromatography.通过尿素萃取和气相色谱法分析谷物水悬浮液中亚油酸的脂氧合酶非挥发性反应产物。
Lipids. 1973 Nov;8(11):599-605. doi: 10.1007/BF02533141.
8
Positional specificity of gamma-ketol formation from linoleic acid hydroperoxides by a corn germ enzyme.玉米胚芽酶催化亚油酸氢过氧化物生成γ-酮醇的位置特异性
Lipids. 1975 Oct;10(10):602-8. doi: 10.1007/BF02532724.
9
Oxygenated fatty acid constituents of soybean phosphatidylcholines.
Lipids. 1977 Jul;12(7):613-9. doi: 10.1007/BF02533391.

本文引用的文献

1
Oxygen transfer in the enzymatic conversion of 18O-labelled linoleic acid hydroperoxide into the 12-keto-13-hydroxyoctadec-cis-9-enoic acid.在将18O标记的亚油酸氢过氧化物酶促转化为12-酮-13-羟基十八碳-顺-9-烯酸过程中的氧转移
FEBS Lett. 1970 Apr 2;7(2):188-190. doi: 10.1016/0014-5793(70)80153-3.
2
A new product of linoleic acid oxidation by a flaxseed enzyme.一种由亚麻籽酶催化亚油酸氧化产生的新产品。
Biochem Biophys Res Commun. 1966 May 25;23(4):398-402. doi: 10.1016/0006-291x(66)90740-6.
3
Proof of the enzymatic formation of 9-hydroperoxy-10-trans, 12-cis-octadecadienoic acid from linoleic acid by soya lipoxygenase.大豆脂氧合酶催化亚油酸生成9-氢过氧-10-反式，12-顺式-十八碳二烯酸的酶促反应证明。
Biochim Biophys Acta. 1970 Feb 10;202(1):198-9. doi: 10.1016/0005-2760(70)90235-3.
4
The enzymic conversions of 13-hydroperoxy-cis-9-trans-11-octadecadienoic acid into 13-hydroxy-12-oxo-cis-9-octadecenoic acid.13-氢过氧-顺-9-反-11-十八碳二烯酸向13-羟基-12-氧代-顺-9-十八碳烯酸的酶促转化。
Biochem J. 1968 Dec;110(4):58P. doi: 10.1042/bj1100058pa.