亚麻籽氢过氧化物异构酶对亚油酸氢过氧化物的酶促转化。
The enzymic conversion of linoleic acid hydroperoxide by flax-seed hydroperoxide isomerase.
作者信息
Veldink G A, Vliegenthart J F, Boldingh J
出版信息
Biochem J. 1970 Nov;120(1):55-60. doi: 10.1042/bj1200055.
Abstract
- The mode of action of flax-seed hydroperoxide isomerase was studied in vitro by using as substrates linoleic acid hydroperoxides formed by soya-bean lipoxygenase. 2. The enzyme converts only 13-hydroperoxyoctadeca-cis-9-trans-11-dienoic acid, whereas the 9-hydroperoxy isomer does not react. 3. The isomerization product was identified by chemical and spectroscopic methods as 13-hydroxy-12-oxo-octadec-cis-9-enoic acid. 4. 12,13-Epoxyoleic acid isomers do not act as intermediates in the isomerization reaction. 5. Suggestions for a functional relationship between hydroperoxide isomerase and lipoxygenase are discussed.
摘要
- 通过使用大豆脂氧合酶形成的亚油酸氢过氧化物作为底物，在体外研究了亚麻籽氢过氧化物异构酶的作用模式。2. 该酶仅能转化13-氢过氧十八碳-顺-9-反-11-二烯酸，而9-氢过氧异构体不发生反应。3. 通过化学和光谱方法将异构化产物鉴定为13-羟基-12-氧代-十八碳-顺-9-烯酸。4. 12,13-环氧油酸异构体在异构化反应中不作为中间体。5. 讨论了氢过氧化物异构酶与脂氧合酶之间功能关系的相关建议。
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本文引用的文献
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Oxygen transfer in the enzymatic conversion of 18O-labelled linoleic acid hydroperoxide into the 12-keto-13-hydroxyoctadec-cis-9-enoic acid.在将18O标记的亚油酸氢过氧化物酶促转化为12-酮-13-羟基十八碳-顺-9-烯酸过程中的氧转移
FEBS Lett. 1970 Apr 2;7(2):188-190. doi: 10.1016/0014-5793(70)80153-3.
2
A new product of linoleic acid oxidation by a flaxseed enzyme.一种由亚麻籽酶催化亚油酸氧化产生的新产品。
Biochem Biophys Res Commun. 1966 May 25;23(4):398-402. doi: 10.1016/0006-291x(66)90740-6.
3
Proof of the enzymatic formation of 9-hydroperoxy-10-trans, 12-cis-octadecadienoic acid from linoleic acid by soya lipoxygenase.大豆脂氧合酶催化亚油酸生成9-氢过氧-10-反式，12-顺式-十八碳二烯酸的酶促反应证明。
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The enzymic conversions of 13-hydroperoxy-cis-9-trans-11-octadecadienoic acid into 13-hydroxy-12-oxo-cis-9-octadecenoic acid.13-氢过氧-顺-9-反-11-十八碳二烯酸向13-羟基-12-氧代-顺-9-十八碳烯酸的酶促转化。
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