Martines G, Piva M, Copponi V, Cagnetta G
Arch Sci Med (Torino). 1979 Jul-Sep;136(3):443-54.
Further systematic study of the relation between drugs and the ultrastructure of the liver is reported with regard to the experimental administration of silimarin to pregnant women and others on the pill. Marked signs of ultrastructural alteration of the REL and biliary cell pole were noted, matched, by evidence of throbophilia and changes in protein activity and lipid synthesis, are noted in these situations, but not when suitable doses of silimarine are taken with the pill. It is suggested that silimarin may prevent and correct liver damage during pregnancy and the administration of oestroprogestins.
关于对孕妇和服用避孕药的其他人进行水飞蓟宾实验给药，报告了对药物与肝脏超微结构之间关系的进一步系统研究。在这些情况下，观察到肝内网状内皮系统（REL）和胆小管细胞极超微结构改变的明显迹象，同时伴有血栓形成倾向以及蛋白质活性和脂质合成变化的证据，但当与避孕药一起服用适当剂量的水飞蓟宾时则未观察到这些情况。有人提出，水飞蓟宾可能预防和纠正孕期及服用雌激素 - 孕激素期间的肝损伤。
