Savkovié N, Pecevski J, Gelineo A
Strahlentherapie. 1975 Dec;150(6):597-602.
The purpose of this investigation is to find out whether streptomycin and the related compound dihydrodeoxystreptomycin have any mutagenic effect and whether they both are capable of recovering X-ray induced chromosomal translocations in mouse spermatogonia of directly treated animals and their progeny of the first generation. The cytological findings show the absence of any mutagenic effect in animals nonirradiated and treated with streptomycin and dihydrodeoxystreptomycin. The frequency of chromosomal translocation after total irradiation was 9,07%; in animals treated with streptomycin following irradiation 5.13%, and in those irradiated and treated with dihyrodeoxystreptomycin, 3.70%. Male offsprings, originated from parents treated only with antibiotics show no chromosomal translocations. However, offsprings originated from irradiated and treated parents gave birth to the male offspring with chromosomal translocations.
本研究的目的是查明链霉素及相关化合物二氢脱氧链霉素是否具有任何诱变作用，以及它们是否都能够恢复直接处理动物及其第一代子代小鼠精原细胞中X射线诱导的染色体易位。细胞学研究结果表明，未接受辐射但用链霉素和二氢脱氧链霉素处理的动物未出现任何诱变作用。全身照射后染色体易位的频率为9.07%；照射后用链霉素处理的动物为5.13%，照射并用二氢脱氧链霉素处理的动物为3.70%。仅用抗生素处理的亲代所产生的雄性子代未出现染色体易位。然而，接受过辐射和处理的亲代所产生的子代生育出了具有染色体易位的雄性子代。
