Pecevski J, Savković N, Radivojević D, Gellineo A, Pergal M
Strahlentherapie. 1977 Mar;153(3):200-3.
Antibiotics, erythromycin and a thiocarbamide derivative of erythromycin were tested for their ability to induce chromosome translocations in whole-body irradiated mice with a dose of 600 r. The aim of the present paper was to determine whether these antibiotics might induce by themselves, chromosomal translocations and whether these agents have a protective effect against X-rays-induced chromosomal translocations in the spermatocytes at the first meiotic metaphase. The incidence of translocations in irradiated animals was 9.07%; in animals treated with erythromycine after irradiation it was 3.80%; and in those treated with a thiocarbamide derivative of erythromycin following irradiation was 3.20%. Not a single chromosome rearrangement was scored among the non-irradiated animals, treated with the mentioned antibiotics.
对抗生素、红霉素及其一种硫脲衍生物进行了测试，观察它们在给全身照射剂量为600伦琴的小鼠体内诱导染色体易位的能力。本文的目的是确定这些抗生素自身是否可能诱导染色体易位，以及这些药物对第一次减数分裂中期精母细胞中X射线诱导的染色体易位是否具有保护作用。受照射动物的易位发生率为9.07%；照射后用红霉素治疗的动物为3.80%；照射后用红霉素硫脲衍生物治疗的动物为3.20%。在接受上述抗生素治疗的未受照射动物中，未发现任何染色体重排。
