Savković N, Pecevski J, Vuksanović L, Radivojević D, Alavantić D
Strahlentherapie. 1983 Jan;159(1):51-3.
The dose-response curve for reciprocal translocations induced by acute exposure of spermatogonial stem cells to X-rays in treated mice and their F-1 sons was examined. Male mice were totally irradiated with doses of 1 Gy; 5 X 1 Gy and 5 Gy. The obtained results show that frequency of the chromosomal translocations in directly treated animals is dose dependent. The percentage of animals irradiated with 1 Gy which had the chromosomal translocations was 60, while this percentage in animals irradiated with single and fractionated dose of 5 Gy was 100. The frequency of chromosomal translocations varies from 1.5% to 8.0%. Multivalent configurations in F-1 males were observed after exposure to 5 Gy only. The incidence of F-1 translocated males was 17.5%.
研究了经处理的小鼠及其F-1代雄性子代精原干细胞急性暴露于X射线诱导相互易位的剂量反应曲线。雄性小鼠分别接受1 Gy、5×1 Gy和5 Gy剂量的全身照射。所得结果表明，直接处理的动物中染色体易位频率与剂量相关。接受1 Gy照射且发生染色体易位的动物百分比为60%，而接受单次和分次5 Gy照射的动物中这一百分比为100%。染色体易位频率在1.5%至8.0%之间变化。仅在接受5 Gy照射后观察到F-1代雄性出现多价构型。F-1代易位雄性的发生率为17.5%。
