Matveeva S A, Maksimov V M, Konradov A A, Barsel' V A
Biol Bull Acad Sci USSR. 1979 Mar-Apr;6(2):226-36.
A mathematical description of the inflow of dibunol from the site of administration and its distribution by organs and tissues in experimental animals and man are examined. Parameters quantitatively characterizing the behavior of the preparation in the organism were obtained. The mechanism of the accumulation of dibunol in the tissues and its subsequent transfer to the blood are described within the framework of the proposed model. The model of the pharmakinetics of dibunol makes possible a calculation of the concentration of the preparation in the tissues depending on the method of administration and special features of the medicinal form. In clinical practice when administered per os microcapsules, which provided maximum absorbability, proved to be the best medicinal form. Satisfactory agreement of the concentrations of the preparation actually observed in a human tumor with those calculated theoretically on the basis of the proposed model was observed.
研究了在实验动物和人体中，地布诺尔从给药部位的流入及其在器官和组织中的分布的数学描述。获得了定量表征该制剂在生物体内行为的参数。在地布诺尔在组织中的蓄积及其随后向血液转移的机制在提出的模型框架内进行了描述。地布诺尔的药代动力学模型使得能够根据给药方法和剂型特点计算制剂在组织中的浓度。在临床实践中，经口给药时，具有最大吸收性的微胶囊被证明是最佳剂型。观察到在人类肿瘤中实际观察到的制剂浓度与根据所提出的模型理论计算的浓度之间具有令人满意的一致性。
