Shatalov V N, Korman D B, Krutova T V, Sokolov L K, Andrianova O P
Farmakol Toksikol. 1988 May-Jun;51(3):60-4.
The antiulcer effect of two medicinal forms (oil solution, liniment) of dibunol in rats with different models of the stomach and duodenum ulcers was studied. The therapeutic activity of dibunol was evaluated by determining the index of ulcer formation as well as during the morphological and histochemical studies. The two medicinal forms of dibunol possessed equal antiulcer activity by all studied criteria. One should note a characteristic property of dibunol--its ability to produce pronounced epithelialization of ulceroerosive and ulceronecrotic lesions of the mucosa without rough scarring.
研究了二丁诺两种剂型（油溶液、搽剂）对不同模型的大鼠胃和十二指肠溃疡的抗溃疡作用。通过测定溃疡形成指数以及进行形态学和组织化学研究来评估二丁诺的治疗活性。根据所有研究标准，二丁诺的两种剂型具有同等的抗溃疡活性。应当指出二丁诺的一个特性——它能够使黏膜的溃疡糜烂和溃疡坏死性病变显著上皮化，而不会形成粗糙瘢痕。
