Baraboĭ V A, Bororov L V, Gunina L M, Maevskaia L P
Eksp Klin Farmakol. 1994 Sep-Oct;57(5):43-5.
Dibunol (butylhydroxytoluene) in 1-g capsules was given to lung cancer patients, 4 g for two days and 4 g for one day before surgery. The level of stress was evaluated by the blood levels of cortisole, by the daily urinary concentrations of 17-keto- and 17-ketogenic steroids, and by the blood levels medium-weight molecular peptides and toxic indices 1, 3, 5-7 days of postsurgery. The antistress action of the agent appeared as twofold decreased blood cortisol and urinary 17-KS and 17-KGS 1 day after surgery, returning to the baseline on day 3 (while there was no normalization even on day 7 if dibunol was not given), and as significantly declined intoxication indices.
给肺癌患者服用装入1克胶囊的二丁基羟基甲苯，术前两天每天服用4克，术前一天服用4克。通过皮质醇的血液水平、17-酮类固醇和17-生酮类固醇的每日尿液浓度、术后1、3、5至7天的血液中中等分子量分子肽水平和毒性指标来评估应激水平。该药物的抗应激作用表现为术后1天血液皮质醇和尿液17-KS及17-KGS水平降低两倍，第3天恢复至基线水平（如果未服用二丁基羟基甲苯，甚至在第7天也未恢复正常），且中毒指标显著下降。
