Fair W R, Couch J, Wehner N
Urology. 1976 Feb;7(2):169-77. doi: 10.1016/0090-4295(76)90305-8.
Normal human prostatic fluid possesses pronounced antibacterial activity. This activity is absent or markedly diminished in the fluid of men with chronic bacterial prostatitis. Ion-probe and mass spectrographic analysis of this antibacterial factor has shown it to be a zinc salt. Prostatic fluid zinc levels in 15 men with chronic bacterial prostatitis averaged 50 mug. per milliliter (range 0 to 139 mug. per milliliter). The zinc level in the expressed prostate secretion (EPS) of 49 control men averaged 448 mug. per milliliter (range 150 to 1,000 mug. per milliliter). There was no overlap in the range of zinc values between the two groups. The decrease in EPS zinc concentration in the patient population was not secondary to a decreased serum zinc level. Exogenous zinc given orally did not increase the EPS zinc level. The decrease in EPS zinc was not limited to infected prostatic fluid cultures and may precede the entry of bacteria into the prostate. The data presented suggest that zinc may serve as an in vivo defense mechanism against prostatic invasion and subsequent urinary tract infections in men.
正常男性前列腺液具有显著的抗菌活性。在患有慢性细菌性前列腺炎的男性的前列腺液中，这种活性缺失或明显减弱。对这种抗菌因子进行离子探针和质谱分析表明，它是一种锌盐。15名患有慢性细菌性前列腺炎的男性的前列腺液锌水平平均为每毫升50微克（范围为每毫升0至139微克）。49名对照男性的前列腺按摩液（EPS）中的锌水平平均为每毫升448微克（范围为每毫升150至1000微克）。两组之间锌值范围没有重叠。患者群体中EPS锌浓度的降低并非继发于血清锌水平的降低。口服外源性锌并未增加EPS锌水平。EPS锌的降低并不局限于感染的前列腺液培养物，且可能在细菌进入前列腺之前就已出现。所呈现的数据表明，锌可能作为一种体内防御机制，抵御男性前列腺的感染及随后的尿路感染。
