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1
The effects of high hydrostatic pressure on the microtubules of Tetrahymena pyriformis.高静水压对梨形四膜虫微管的影响。
J Cell Biol. 1970 Dec;47(3):568-76. doi: 10.1083/jcb.47.3.568.
2
Ciliary membrane differentiations in Tetrahymena pyriformis. Tetrahymena has four types of cilia.梨形四膜虫的纤毛膜分化。四膜虫有四种类型的纤毛。
J Cell Biol. 1974 Aug;62(2):473-90. doi: 10.1083/jcb.62.2.473.
3
The termination of the central microtubules from the cilia of Tetrahymena pyriformis.梨形四膜虫纤毛中央微管的终止。
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4
180 degrees rotation of ciliary rows and its morphogenetic implications in Tetrahymena pyriformis.梨形四膜虫纤毛排的180度旋转及其形态发生意义
Proc Natl Acad Sci U S A. 1977 Mar;74(3):1115-9. doi: 10.1073/pnas.74.3.1115.
5
Subunit arrangement in ciliary microtubules from Tetrahymena pyriformis.梨形四膜虫纤毛微管中的亚基排列
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6
Structure and organization of radial spokes in cilia of Tetrahymena pyriformis.梨形四膜虫纤毛中辐条的结构与组织
J Morphol. 1977 Jul;153(1):143-51. doi: 10.1002/jmor.1051530110.
7
Splayed Tetrahymena cilia. A system for analyzing sliding and axonemal spoke arrangements.伸展的四膜虫纤毛。一种用于分析滑动和轴丝辐条排列的系统。
J Cell Biol. 1976 Nov;71(2):589-605. doi: 10.1083/jcb.71.2.589.
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Ciliary microtubule capping structures contain a mammalian kinetochore antigen.纤毛微管帽结构含有一种哺乳动物动粒抗原。
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Shape of the ciliary doublet microtubule in solution.溶液中睫状双微管的形状。
J Mol Biol. 1982 Jun 25;158(2):317-24. doi: 10.1016/0022-2836(82)90436-3.

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A polarized multicomponent foundation upholds ciliary central microtubules.一个极化的多组分基础支撑着纤毛中央微管。
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Explaining bathymetric diversity patterns in marine benthic invertebrates and demersal fishes: physiological contributions to adaptation of life at depth.解释海洋底栖无脊椎动物和底层鱼类的测深多样性模式：深度生活适应的生理贡献。
Biol Rev Camb Philos Soc. 2014 May;89(2):406-26. doi: 10.1111/brv.12061. Epub 2013 Oct 4.
3
Microtubule biogenesis and cell shape in Ochromonas. II. The role of nucleating sites in shape development.赭球藻中的微管生物发生与细胞形态。II. 成核位点在形态发育中的作用。
J Cell Biol. 1973 Feb;56(2):360-78. doi: 10.1083/jcb.56.2.360.
4
Stability of neuronal microtubules to high pressure in vivo and in vitro.神经元微管在体内和体外对高压的稳定性。
Proc Natl Acad Sci U S A. 1974 Oct;71(10):4198-202. doi: 10.1073/pnas.71.10.4198.
5
Two alpha-tubulin genes of Aspergillus nidulans encode divergent proteins.构巢曲霉的两个α-微管蛋白基因编码不同的蛋白质。
Mol Gen Genet. 1991 Jan;225(1):129-41. doi: 10.1007/BF00282651.
6
The effect of antimicrotubule agents on the growth and ultrastructure of the fungus Saprolegnia ferax and their ineffectiveness in disrupting hyphal microtubules.抗微管药物对真菌水霉生长及超微结构的影响及其在破坏菌丝微管方面的无效性。
Protoplasma. 1975;85(2-4):147-76. doi: 10.1007/BF01567943.
7
Disagreement between calorimetric and van't Hoff enthalpies of assembly of protein supramolecular structures.蛋白质超分子结构组装的量热焓与范特霍夫焓之间的差异。
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本文引用的文献

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The mechanisms of cell division; temperature-pressure experiments on the cleaving eggs of Arbacia punctulata.细胞分裂的机制；对海胆卵分裂进行的温度-压力实验。
J Cell Comp Physiol. 1950 Oct;36(2):205-27. doi: 10.1002/jcp.1030360207.
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The use of lead citrate at high pH as an electron-opaque stain in electron microscopy.在电子显微镜检查中，将高pH值的柠檬酸铅用作电子不透明染色剂。
J Cell Biol. 1963 Apr;17(1):208-12. doi: 10.1083/jcb.17.1.208.
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The micromorphology of Amoeba proteus during pressure-induced changes in the sol-gel cycle.变形虫在压力诱导的溶胶-凝胶循环变化过程中的微观形态。
Exp Cell Res. 1962 Sep;27:591-4. doi: 10.1016/0014-4827(62)90027-7.
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Improvements in epoxy resin embedding methods.环氧树脂包埋方法的改进。
J Biophys Biochem Cytol. 1961 Feb;9(2):409-14. doi: 10.1083/jcb.9.2.409.
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The pellicle as a factor in the stabilization of cellular form and integrity: effects of externally applied enzymes on the resistance of Blepharisma and Paramecium to pressure-induced cytolysis.表膜作为细胞形态稳定和完整性的一个因素：外部施加的酶对草履虫和尾草履虫抗压诱导细胞溶解抗性的影响。
J Cell Comp Physiol. 1961 Aug;58:49-61. doi: 10.1002/jcp.1030580107.
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Isolation of a protein subunit from microtubules.从微管中分离出一种蛋白质亚基。
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7
Studies on the microtubules in heliozoa. II. The effect of low temperature on these structures in the formation and maintenance of the axopodia.太阳虫微管的研究。II. 低温对轴足形成和维持过程中这些结构的影响。
J Cell Biol. 1967 Jul;34(1):327-43. doi: 10.1083/jcb.34.1.327.
8
Studies on the microtubules in heliozoa. 3. A pressure analysis of the role of these structures in the formation and maintenance of the axopodia of Actinosphaerium nucleofilum (Barrett).太阳虫微管的研究。3. 对这些结构在多核太阳虫轴伪足形成和维持中作用的压力分析（巴雷特）
J Cell Biol. 1966 Apr;29(1):77-95. doi: 10.1083/jcb.29.1.77.
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Studies on the microtubules in heliozoa. V. Factors controlling the organization of microtubules in the Axonemal pattern in Echinosphaerium (Actinosphaerium) nucleofilum.太阳虫微管的研究。V. 控制棘球太阳虫（核丝太阳虫）轴丝模式中微管组织的因素。
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10
The morphogenesis of basal bodies and accessory structures of the cortex of the ciliated protozoan Tetrahymena pyriformis.梨形四膜虫纤毛皮层基体及附属结构的形态发生
J Cell Biol. 1969 Mar;40(3):716-33. doi: 10.1083/jcb.40.3.716.

高静水压对梨形四膜虫微管的影响。

The effects of high hydrostatic pressure on the microtubules of Tetrahymena pyriformis.

作者信息

Kennedy J R, Zimmerman A M

出版信息

J Cell Biol. 1970 Dec;47(3):568-76. doi: 10.1083/jcb.47.3.568.

DOI:10.1083/jcb.47.3.568
PMID:5497538
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2108149/
Abstract

Exposure of Tetrahymena pyriformis to 7,500 or 10,000 psi of hydrostatic pressure for 2, 5, or 10 min intervals results in a change in cell shape and ciliary activity. Shape changes occur concurrently with a degradation of longitudinal microtubules in a posterior to anterior direction. High pressure also causes a disruption of ciliary activity. Fine structural analysis reveals a breakdown (presumably microtubule depolymerization) of the central ciliary microtubules. The depolymerization begins at the junction of the central ciliary microtubules with the axosome and progresses distally along the ciliary shaft for a distance of about 0.5 micro.

摘要

将梨形四膜虫暴露于7500或10000磅/平方英寸的静水压力下2、5或10分钟，会导致细胞形状和纤毛活动发生变化。形状变化与纵向微管从后向前方向的降解同时发生。高压还会导致纤毛活动中断。精细结构分析显示中央纤毛微管出现断裂（推测为微管解聚）。解聚始于中央纤毛微管与轴体的连接处，并沿纤毛轴远端延伸约0.5微米的距离。