瓜罗阿病毒对小鼠中Friend白血病病毒感染的增强作用：各种致癌和非致癌病毒的定量及作用
Enhancement of Friend leukemia virus infection in mice by Guaroa virus: quantitation and action of various oncogenic and nononcogenic viruses.
作者信息
Spahn G J, Turner W, Peters R L, Chirigos M A
出版信息
Appl Microbiol. 1970 Oct;20(4):551-4. doi: 10.1128/am.20.4.551-554.1970.
Abstract
Previous studies have indicated that Guaroa virus (GV), an arbovirus, enhanced the replication of Friend leukemia virus (FLV) in mice. To study further the interaction of GV and FLV, different levels of FLV activity were inoculated into mice. At a level of activity capable of producing limited splenic response, coinfection with GV resulted in a marked increase in spleen-foci activity, mean spleen weight, and amount of infectious virus recoverable from plasma and spleen of dually infected mice. Various oncogenic and nononcogenic viruses were also tested for their ability to enhance FLV infection.
摘要
先前的研究表明，瓜罗阿病毒（GV），一种虫媒病毒，可增强小鼠体内弗氏白血病病毒（FLV）的复制。为了进一步研究GV与FLV的相互作用，将不同水平的FLV活性接种到小鼠体内。在能够产生有限脾脏反应的活性水平下，与GV共同感染导致脾脏病灶活性、平均脾脏重量以及从双重感染小鼠的血浆和脾脏中可回收的传染性病毒量显著增加。还测试了各种致癌和非致癌病毒增强FLV感染的能力。
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