Woods W A, Turner W, Chirigos M A
Appl Microbiol. 1972 Feb;23(2):372-6. doi: 10.1128/am.23.2.372-376.1972.
Enhancement of tumor induction by oncornaviruses through a dual viral infection has been described by several investigators. The mechanism(s) of this enhancement has not as yet been determined. By using a murine sarcoma virus and a Bunyawera group arbovirus (Guaroa virus) in an in vitro system, evidence was obtained for enhancement of the oncogenic potential of the viruses by genetic interaction with the nononcogenic virus as well as the production of increased amounts of the oncogenic virus. These results confirm and extend similar responses obtained in in vivo systems.
几位研究者描述了通过双重病毒感染来增强肿瘤病毒诱导肿瘤的能力。这种增强作用的机制尚未确定。通过在体外系统中使用鼠肉瘤病毒和布尼亚韦拉属虫媒病毒（瓜罗阿病毒），获得的证据表明，通过与非致癌病毒的基因相互作用以及致癌病毒产量的增加，病毒的致癌潜力得到了增强。这些结果证实并扩展了在体内系统中获得的类似反应。
