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[对乳腺癌患者血清与牛奶抗原交叉反应以及从人喉表皮样癌细胞(HEp - 2细胞)分离出的D型肿瘤病毒之间可检测抗原性质的研究(作者译)]

[Study of the nature of the antigens detectable in antiserum cross reactions to the milk antigens of patients with breast carcinoma and to the type D oncornavirus isolated from HEp-2 cells (author's transl)].

作者信息

Kriukova I N, Il'in K V, Spure Zh Zh

出版信息

Vopr Virusol. 1975 Sep-Oct(5):533-6.

PMID:54995
Abstract

Antigens of milk from normal women and from patients with mammary gland carcinoma and antigens of D type virus from HEp-2 cells were studied by means of microprecipitation in the gel and indirect immunofluorecence tests. An antiserum to HEp2 virus precipitated antigens of some milk specimens from cancer patients. However their virus precipitated antigens of some milk specimens from cancer patients. However their precipitation line was not identical to that of the test-system for group-specific antigens and the antiserum to HE-2 virus detected an antigen localized in the cytoplasm in the following cells: HEp-2, continuous cell lines and imprints of human mammary gland cancer, and epithelial cells from milk of patients with mammary gland carcinoma and from milk of normal women. The antiserum for the antigen of milk from cancer patients absorbed with HEp-2 cell homogenate lost its activity in the IF test. The nature of the detected antigens is discussed.

摘要

通过凝胶中的微量沉淀和间接免疫荧光试验,研究了正常女性乳汁、乳腺癌患者乳汁中的抗原以及来自HEp-2细胞的D型病毒抗原。一种针对HEp2病毒的抗血清沉淀了一些癌症患者乳汁样本中的抗原。然而,它们的病毒沉淀了一些癌症患者乳汁样本中的抗原。然而,它们的沉淀线与群特异性抗原检测系统的沉淀线不同,并且针对HE-2病毒的抗血清在以下细胞的细胞质中检测到一种定位抗原:HEp-2、连续细胞系以及人乳腺癌印记,还有乳腺癌患者乳汁和正常女性乳汁中的上皮细胞。用HEp-2细胞匀浆吸收的癌症患者乳汁抗原的抗血清在免疫荧光试验中失去了活性。对检测到的抗原的性质进行了讨论。

相似文献

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Immunologic study of an oncornavirus isolated from a human cancer cell line.
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