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乳腺癌患者乳汁中抗原的免疫学研究及核酸分子杂交

Immunologic study of antigens and molecular hybridization of nucleic acids from milk of breast cancer patients.

作者信息

Kryukova I N, Ilyin K V, Mazurenko N N, Vasilevskaya L N, Zhdanov V M

出版信息

Neoplasma. 1975;22(3):235-41.

PMID:808743
Abstract

Comparative study has shown that by the gel diffusion assay both anti-HEp-2 virus serum and anti-breast cancer milk ultrasediment serum precipitated an identical antigen in human milk specimens, which was not identical with the group specific antigen of the HEp-2 virus. At the same time tha anti-breast cancer milk serum did not precipitate the HEp-2 virus. However, molecular hybridization experiments revealed nucleotide sequences homologous to nucleic acids of oncornavirus of D-type in milk obtained from breast carcinoma patients as well as in milk of healthy donors.

摘要

对比研究表明,通过凝胶扩散试验,抗HEp-2病毒血清和抗乳腺癌乳汁超沉淀物血清在人乳标本中沉淀出一种相同的抗原,该抗原与HEp-2病毒的群特异性抗原不同。同时,抗乳腺癌乳汁血清不能沉淀HEp-2病毒。然而,分子杂交实验显示,从乳腺癌患者乳汁以及健康供体乳汁中获取的乳汁中存在与D型肿瘤病毒核酸同源的核苷酸序列。

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