禁食对体外肠道糖类和氨基酸转运的影响。

Effects of fasting on intestinal transfer of sugars and amino acids in vitro.

作者信息

Newey H, Sanford P A, Smyth D H

出版信息

J Physiol. 1970 Jul;208(3):705-24. doi: 10.1113/jphysiol.1970.sp009144.

DOI:10.1113/jphysiol.1970.sp009144

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1348794/

Abstract

Transfer of sugars, amino acids and fluid and metabolism of glucose were studied with everted sacs of small intestine prepared from fed and 3-day fasted rats.2. In the absence of glucose there was some evidence for increased intestinal transfer of sugars and amino acids in fasted animals. In the presence of glucose there was in general decrease in transfer of amino acids and fluid.3. In fasted animals glucose transfer was reduced except in the lower ileum, and there was a general reduction in glucose metabolism.4. Because of the large reduction in gut weight in fasted animals, expressing transfer on a weight basis is considered not to be a valid procedure in studying the effects of fasting on intestinal transfer.5. The results have been discussed in relation to effects of fasting on energy availability, efficiency of transfer mechanisms, permeability of the intestine and the value of in vitro methods in the study of physiological absorption.

摘要

利用从喂食和禁食3天的大鼠制备的小肠外翻囊，研究了糖、氨基酸和液体的转运以及葡萄糖的代谢。
在没有葡萄糖的情况下，有证据表明禁食动物肠道中糖和氨基酸的转运增加。在有葡萄糖存在时，氨基酸和液体的转运总体上减少。
在禁食动物中，除了回肠下段外，葡萄糖转运减少，并且葡萄糖代谢总体上降低。
由于禁食动物的肠道重量大幅减轻，以重量为基础来表示转运量被认为不是研究禁食对肠道转运影响的有效方法。
已结合禁食对能量供应、转运机制效率、肠道通透性以及体外方法在生理吸收研究中的价值的影响来讨论这些结果。