• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

动物组织中尿苷二磷酸葡萄糖醛酸浓度的测定及合成

Measurement of uridine diphosphate glucuronic acid concentrations and synthesis in animal tissues.

作者信息

Zhivkov V

出版信息

Biochem J. 1970 Dec;120(3):505-8. doi: 10.1042/bj1200505.

DOI:10.1042/bj1200505
PMID:5499963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1179630/
Abstract
  1. A method for the isolation from animal tissues of UDP-glucuronic acid by one-dimensional paper chromatography is described and its concentrations in some tissues of several species of vertebrates are reported; the incorporation of [(32)P]-phosphate into UDP-glucuronic acid in vivo was also investigated. 2. The concentration of UDP-glucuronic acid was higher in the liver of rats, rabbits and guinea pigs than in the same tissue of some species of birds, amphibia and fishes; also, the concentration of UDP-glucuronic acid in rat liver, kidney and small intestine was several times lower than that of the same tissues of guinea pigs. 3. The rate of [(32)P]-phosphate incorporation into UDP-glucuronic acid was very high in rat liver and kidney and almost reached equilibrium with the radioactivity of UDP-glucose 30min after the administration of the [(32)P]phosphate.
摘要
  1. 描述了一种通过一维纸色谱法从动物组织中分离UDP-葡萄糖醛酸的方法，并报告了其在几种脊椎动物某些组织中的浓度；还研究了体内[(32)P]-磷酸盐掺入UDP-葡萄糖醛酸的情况。2. 大鼠、兔子和豚鼠肝脏中UDP-葡萄糖醛酸的浓度高于某些鸟类、两栖动物和鱼类相同组织中的浓度；此外，大鼠肝脏、肾脏和小肠中UDP-葡萄糖醛酸的浓度比豚鼠相同组织中的浓度低几倍。3. 在大鼠肝脏和肾脏中，[(32)P]-磷酸盐掺入UDP-葡萄糖醛酸的速率非常高，在给予[(32)P]磷酸盐30分钟后，几乎与UDP-葡萄糖的放射性达到平衡。
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8eea/1179630/68b4397af176/biochemj00665-0068-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8eea/1179630/0234083fbc1f/biochemj00665-0067-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8eea/1179630/68b4397af176/biochemj00665-0068-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8eea/1179630/0234083fbc1f/biochemj00665-0067-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8eea/1179630/68b4397af176/biochemj00665-0068-a.jpg

相似文献

1
Measurement of uridine diphosphate glucuronic acid concentrations and synthesis in animal tissues.动物组织中尿苷二磷酸葡萄糖醛酸浓度的测定及合成
Biochem J. 1970 Dec;120(3):505-8. doi: 10.1042/bj1200505.
2
Hepatic UDP-glucose and UDP-glucuronic acid synthesis rates in rats during a reduced energy state.能量状态降低期间大鼠肝脏中UDP-葡萄糖和UDP-葡萄糖醛酸的合成速率。
Drug Metab Dispos. 1987 May-Jun;15(3):281-8.
3
Hepatic UDP-glucuronic acid regulation during acetaminophen biotransformation in rats.大鼠对乙酰氨基酚生物转化过程中肝脏UDP-葡萄糖醛酸的调节
J Pharmacol Exp Ther. 1986 Jun;237(3):750-6.
4
Piperine-mediated inhibition of glucuronidation activity in isolated epithelial cells of the guinea-pig small intestine: evidence that piperine lowers the endogeneous UDP-glucuronic acid content.胡椒碱对豚鼠小肠离体上皮细胞葡萄糖醛酸化活性的抑制作用：胡椒碱降低内源性尿苷二磷酸葡萄糖醛酸含量的证据。
J Pharmacol Exp Ther. 1986 Feb;236(2):488-93.
5
Borate-aided anion exchange high-performance liquid chromatography of uridine diphosphate-sugars in brain, heart, adipose and liver tissues.硼酸盐辅助的尿苷二磷酸-糖在脑、心、脂肪和肝组织中的阴离子交换高效液相色谱法。
J Chromatogr A. 2014 Jan 3;1323:82-6. doi: 10.1016/j.chroma.2013.11.004. Epub 2013 Nov 11.
6
Structures of bilirubin conjugates synthesized in vitro from bilirubin and uridine diphosphate glucuronic acid, uridine diphosphate glucose or uridine diphosphate xylose by preparations from rat liver.通过大鼠肝脏提取物，由胆红素与尿苷二磷酸葡萄糖醛酸、尿苷二磷酸葡萄糖或尿苷二磷酸木糖在体外合成的胆红素共轭物的结构。
Biochem J. 1972 Sep;129(3):635-44. doi: 10.1042/bj1290635.
7
[Radioenzymatic micromethod for the determination of UDP-glucuronic acid (author's transl)].[测定尿苷二磷酸葡糖醛酸的放射酶微量法（作者译）]
J Clin Chem Clin Biochem. 1979 Jun;17(6):363-7.
8
Synthesis, characterization and properties of uridine 5'-( -D-apio-D-furanosyl pyrophosphate).尿苷5'-（-D-阿卓-D-呋喃糖基焦磷酸）的合成、表征及性质
Biochem J. 1973 Jun;133(2):227-41. doi: 10.1042/bj1330227.
9
Uridine diphosphate glucuronic acid production and utilization in various tissues actively synthesizing glycosaminoglycans.在各种积极合成糖胺聚糖的组织中尿苷二磷酸葡糖醛酸的产生与利用。
Biochem J. 1972 Jun;128(2):215-27. doi: 10.1042/bj1280215.
10
Depletion of hepatic UDP-glucuronic acid by drugs that are glucuronidated.被葡萄糖醛酸化的药物导致肝脏UDP-葡萄糖醛酸的耗竭。
J Pharmacol Exp Ther. 1986 Mar;236(3):610-4.

引用本文的文献

1
Liver snips. A simple, rapid and reproducible method for studying metabolism in small fragments of tissue, as applied to glucuronidation in rat liver.肝组织小块。一种用于研究小块组织代谢的简单、快速且可重复的方法，应用于大鼠肝脏的葡萄糖醛酸化。
Biochem J. 1982 Feb 15;202(2):469-73. doi: 10.1042/bj2020469.
2
Transcriptional control of ribosome production in regenerating rat liver.再生大鼠肝脏中核糖体生成的转录调控
Biochem J. 1982 Oct 15;208(1):101-8. doi: 10.1042/bj2080101.
3
Steroid glucuronyltransferases of rat liver. Properties of oestrone and testosterone glucuronyltransferases and the effect of ovariectomy, castration and administration of steroids on the enzymes.

本文引用的文献

1
Filter-paper partition chromatography of sugars: 1. General description and application to the qualitative analysis of sugars in apple juice, egg white and foetal blood of sheep. with a note by R. G. Westall.糖类的滤纸分配色谱法：1. 概述及其在苹果汁、蛋清和绵羊胎儿血液中糖类定性分析的应用。附R.G.韦斯托尔的注释
Biochem J. 1948;42(2):238-50. doi: 10.1042/bj0420238.
2
An improved method for the colorimetric determination of phosphate.一种改进的比色法测定磷酸盐的方法。
Biochem J. 1938 Feb;32(2):295-8. doi: 10.1042/bj0320295.
3
Isolation of the coenzyme of the galactose phosphate-glucose phosphate transformation.
大鼠肝脏的类固醇葡萄糖醛酸转移酶。雌酮和睾酮葡萄糖醛酸转移酶的特性以及卵巢切除、阉割和类固醇给药对这些酶的影响。
Biochem J. 1977 Mar 15;162(3):545-56. doi: 10.1042/bj1620545.
4
The biosynthesis of tyramine glucuronide by liver microsomal fractions.肝脏微粒体组分对酪胺葡糖醛酸苷的生物合成。
Biochem J. 1977 Jun 15;164(3):529-31. doi: 10.1042/bj1640529.
磷酸半乳糖 - 磷酸葡萄糖转化辅酶的分离。
J Biol Chem. 1950 May;184(1):333-50.
4
Uridine compounds in glucuronic acid metabolism. 2. The isolation and structure of 'uridine-diphosphate-glucuronic acid'.葡萄糖醛酸代谢中的尿苷化合物。2. “尿苷二磷酸葡萄糖醛酸”的分离与结构
Biochem J. 1955 Feb;59(2):279-88. doi: 10.1042/bj0590279.
5
A modified uronic acid carbazole reaction.一种改良的糖醛酸咔唑反应。
Anal Biochem. 1962 Oct;4:330-4. doi: 10.1016/0003-2697(62)90095-7.
6
Isolation, detection and measure of microgram quantities of labeled tissue nucleotides.微克量标记组织核苷酸的分离、检测与测定。
Arch Biochem Biophys. 1959 Mar;81(1):223-37. doi: 10.1016/0003-9861(59)90192-4.
7
Uridine compounds in glucuronic acid metabolism. I. The formation of glucuronides in liver suspensions.葡萄糖醛酸代谢中的尿苷化合物。I. 肝混悬液中葡萄糖醛酸苷的形成。
Biochem J. 1954 Jun;57(2):275-83. doi: 10.1042/bj0570275.
8
Uridine nucleotide compounds of liver.肝脏的尿苷核苷酸化合物
Biochim Biophys Acta. 1954 Mar;13(3):386-400. doi: 10.1016/0006-3002(54)90346-7.
9
The isolation of a compound of uridine diphosphate and glucuronic acid from liver.
Biochem J. 1953 Mar;53(4):xxxvii-xxxviii.
10
Studies on uridine-diphosphate-glucose.尿苷二磷酸葡萄糖的研究。
Biochem J. 1952 Jun;51(3):426-30. doi: 10.1042/bj0510426.