牛血清中甲状腺素的释放率和结合率。
The rates of release and binding of thyroxine by bovine serum.
作者信息
Hillier A P
出版信息
J Physiol. 1970 Jun;208(2):473-83. doi: 10.1113/jphysiol.1970.sp009132.
Abstract
- Estimates have been made of the rates of release and binding of thyroxine by bovine serum proteins. The method involves measuring the rates at which columns of Amberlite resin take up thyroxine from serum.2. At 37 degrees C the dissociation rate (the rate of release of bound thyroxine into free solution) is about 2.2% sec(-1).3. The binding of thyroxine by serum is a complex process, the majority of the hormone being ;loosely' bound within 0.1 sec but the over-all process taking some 20 sec to completion.4. A mechanism is proposed for the uptake of thyroxine by the liver. It involves a simple competition between the plasma and the liver binding sites for the free thyroxine released into solution by the dissociation reaction.
摘要
已对牛血清蛋白释放和结合甲状腺素的速率进行了估算。该方法包括测量 Amberlite 树脂柱从血清中摄取甲状腺素的速率。
在 37 摄氏度时，解离速率（结合的甲状腺素释放到游离溶液中的速率）约为 2.2% 秒⁻¹。
血清对甲状腺素的结合是一个复杂的过程，大部分激素在 0.1 秒内“松散”结合，但整个过程大约需要 20 秒才能完成。
提出了一种肝脏摄取甲状腺素的机制。它涉及血浆和肝脏结合位点之间对解离反应释放到溶液中的游离甲状腺素的简单竞争。
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The rates of release and binding of thyroxine by bovine serum.牛血清中甲状腺素的释放率和结合率。
J Physiol. 1970 Jun;208(2):473-83. doi: 10.1113/jphysiol.1970.sp009132.
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引用本文的文献
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The binding of thyroid hormones to phospholipid membranes.甲状腺激素与磷脂膜的结合。
J Physiol. 1970 Dec;211(3):585-97. doi: 10.1113/jphysiol.1970.sp009295.
2
The mechanism of thyroxine transfer from plasma to tissue binding sites.甲状腺素从血浆转移至组织结合位点的机制。
J Physiol. 1971 Sep;217(3):635-9. doi: 10.1113/jphysiol.1971.sp009590.
3
Human thyroxine-binding globulin and thyroxine-binding pre-albumin: dissociation rates.人甲状腺素结合球蛋白和甲状腺素结合前白蛋白：解离速率
J Physiol. 1971 Sep;217(3):625-34. doi: 10.1113/jphysiol.1971.sp009589.
4
Active secretion of thyroxine into bile: the role of tissue thyroxine-binding sites.甲状腺素向胆汁中的主动分泌：组织甲状腺素结合位点的作用。
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本文引用的文献
1
Proteins associated with the thyroid hormones.与甲状腺激素相关的蛋白质。
Physiol Rev. 1960 Jul;40:415-89. doi: 10.1152/physrev.1960.40.3.415.
2
Regulation of the peripheral metabolism of the thyroid hormones.甲状腺激素外周代谢的调节。
Recent Prog Horm Res. 1960;16:353-403.
3
Direct measurement of hepatic thyroxine flux in normal man.正常人体内肝脏甲状腺素通量的直接测量。
J Clin Endocrinol Metab. 1968 Oct;28(10):1503-7. doi: 10.1210/jcem-28-10-1503.
4
The release of thyroxine from serum protein in the vessels of the liver.甲状腺素从肝脏血管中的血清蛋白释放出来。
J Physiol. 1969 Aug;203(2):419-34. doi: 10.1113/jphysiol.1969.sp008872.
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