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钙离子对大鼠空肠切片转运长链脂肪酸的影响。

The effect of calcium ions on long chain fatty acid transport by slices of rat jejunum.

作者信息

Munday K A, Parsons B J, York D A

出版信息

J Physiol. 1970 Dec;211(3):517-26. doi: 10.1113/jphysiol.1970.sp009290.

DOI:10.1113/jphysiol.1970.sp009290
PMID:5501048
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1396084/
Abstract
  1. There is a large increase in palmitic acid uptake by rat jejunum slices when incubated in the presence of calcium. This effect is observed at both 37 and at 0 degrees C.2. The presence or absence of calcium in the incubation medium does not affect triglyceride synthesis from absorbed fatty acid.3. The release of synthesized triglyceride from the tissue into the medium is increased by calcium.4. The probability that calcium transport and long chain fatty acid transport may be interrelated at both the brush border and at the basal and lateral membranes of the intestinal mucosal epithelial cell is discussed.
摘要
  1. 当在有钙存在的情况下孵育时,大鼠空肠切片对棕榈酸的摄取大幅增加。在37摄氏度和0摄氏度时均观察到这种效应。

  2. 孵育培养基中钙的存在与否不影响由吸收的脂肪酸合成甘油三酯。

  3. 钙可增加合成的甘油三酯从组织释放到培养基中的量。

  4. 讨论了在肠黏膜上皮细胞的刷状缘以及基底膜和侧膜处钙转运与长链脂肪酸转运可能相互关联的可能性。

相似文献

1
The effect of calcium ions on long chain fatty acid transport by slices of rat jejunum.钙离子对大鼠空肠切片转运长链脂肪酸的影响。
J Physiol. 1970 Dec;211(3):517-26. doi: 10.1113/jphysiol.1970.sp009290.
2
Studies on the uptake of fatty acids by brush border membranes of the rabbit intestine.兔肠道刷状缘膜对脂肪酸摄取的研究。
Can J Biochem Cell Biol. 1985 Apr;63(4):249-56. doi: 10.1139/o85-036.
3
Calcium uptake by jejunal brush border membrane of the diabetic rat.
Diabetes Res. 1991 May;17(1):43-9.
4
Effects of taurodeoxycholate on in vivo water and solute transport in rat jejunum in absence and presence of calcium.牛磺脱氧胆酸盐在有无钙的情况下对大鼠空肠体内水和溶质转运的影响。
Am J Physiol. 1986 Feb;250(2 Pt 1):G248-51. doi: 10.1152/ajpgi.1986.250.2.G248.
5
The duration of medium-chain triglyceride feeding determines brush border membrane lipid composition and hydrolase activity in newly weaned rats.中链甘油三酯喂养的持续时间决定了刚断奶大鼠的刷状缘膜脂质组成和水解酶活性。
J Nutr. 1996 May;126(5):1455-62. doi: 10.1093/jn/126.5.1455.
6
Intestinal transport of calcium in rat biliary cirrhosis.
Pediatr Res. 1996 Oct;40(4):533-41. doi: 10.1203/00006450-199610000-00004.
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Fatty acid binding protein. Role in esterification of absorbed long chain fatty acid in rat intestine.脂肪酸结合蛋白。在大鼠肠道中对吸收的长链脂肪酸酯化作用中的角色。
J Clin Invest. 1976 Sep;58(3):632-41. doi: 10.1172/JCI108510.
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Oleic acid uptake by jejunal and ileal rat brush border membrane vesicles.大鼠空肠和回肠刷状缘膜囊泡对油酸的摄取
Eur J Med Res. 1996 Jan 19;1(4):199-203.
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The uptake of oleic acid by rat small intestine: a comparison of methodologies.大鼠小肠对油酸的摄取:方法学比较
J Lipid Res. 1971 Jan;12(1):43-55.
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Role of a brush border membrane fatty acid binding protein in oleic acid uptake into rat and rabbit jejunal brush border membrane.刷状缘膜脂肪酸结合蛋白在油酸进入大鼠和兔空肠刷状缘膜过程中的作用
Clin Invest Med. 1995 Oct;18(5):380-8.

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J Cell Mol Med. 2023 Sep;27(18):2631-2642. doi: 10.1111/jcmm.17853. Epub 2023 Aug 28.
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The passage of calcium and strontium across the gut of the anaesthetized goat.
J Physiol. 1972 Apr;222(2):397-406. doi: 10.1113/jphysiol.1972.sp009804.
3
Coronary vasodilation by fatty acids.脂肪酸引起的冠状动脉血管舒张。
Basic Res Cardiol. 1976 Mar-Apr;71(2):179-91. doi: 10.1007/BF01927870.

本文引用的文献

1
Transport of amino acids by slices of rat-kidney cortex.大鼠肾皮质切片对氨基酸的转运
Biochim Biophys Acta. 1961 Dec 23;54:479-88. doi: 10.1016/0006-3002(61)90088-9.
2
SITES OF CALCIUM ABSORPTION AND THE CALCIUM CONCENTRATION OF GUT CONTENTS IN THE DOG.
Can J Physiol Pharmacol. 1965 Jan;43:75-8. doi: 10.1139/y65-009.
3
PROTEIN SYNTHESIS INHIBITION: MECHANISM FOR THE PRODUCTION OF IMPAIRED FAT ABSORPTION.蛋白质合成抑制:脂肪吸收受损产生的机制
Science. 1965 Mar 5;147(3662):1149-51. doi: 10.1126/science.147.3662.1149.
4
THE INTESTINAL ABSORPTION AND METABOLISM OF MICELLAR SOLUTIONS OF LIPIDS.脂质胶束溶液在小鼠体内的肠道吸收与代谢
Biochim Biophys Acta. 1964 Aug 5;84:412-23. doi: 10.1016/0926-6542(64)90005-8.
5
STIMULUS-SECRETION COUPLING IN A NEUROSECRETORY ORGAN: THE ROLE OF CALCIUM IN THE RELEASE OF VASOPRESSIN FROM THE NEUROHYPOPHYSIS.神经分泌器官中的刺激-分泌偶联:钙在神经垂体释放血管加压素中的作用。
J Physiol. 1964 Jul;172(1):1-18. doi: 10.1113/jphysiol.1964.sp007399.
6
Hypothesis for mechanism of intestinal active transport of sugars.糖的肠道主动转运机制假说。
Fed Proc. 1962 Nov-Dec;21:891-5.
7
The role of calcium in the secretory response of the adrenal medulla to acetylcholine.钙在肾上腺髓质对乙酰胆碱分泌反应中的作用。
J Physiol. 1961 Nov;159(1):40-57. doi: 10.1113/jphysiol.1961.sp006791.
8
Studies on lipid metabolism in the small intestine with observations on the role of bile salts.关于小肠脂质代谢的研究以及对胆盐作用的观察。
J Clin Invest. 1960 May;39(5):730-40. doi: 10.1172/JCI104090.
9
An electron microscopic study of the intestinal villus. II. The pathway of fat absorption.小肠绒毛的电子显微镜研究。II. 脂肪吸收途径。
J Biophys Biochem Cytol. 1959 May 25;5(3):373-84. doi: 10.1083/jcb.5.3.373.
10
Factors affecting digestibility of fatty acids in the rat.影响大鼠脂肪酸消化率的因素。
J Nutr. 1958 Mar 10;64(3):411-24. doi: 10.1093/jn/64.3.411.