胆碱能和肾上腺素能阻断剂对小汗腺活动的影响。
Effects of cholinergic and adrenergic blocking agents on the activity of the eccrine sweat glands.
作者信息
Foster K G, Weiner J S
出版信息
J Physiol. 1970 Nov;210(4):883-95. doi: 10.1113/jphysiol.1970.sp009247.
Abstract
- The effects of blocking agents on the responsiveness of the cast' pad and human forearm sweat glands have been studied.2. Of the anti-adrenergic substances examined (dibenamine, phenoxybenzamine, bretylium, guanethidine and phentolamine) only high doses of guanethidine and phentolamine produced any consistent and significant measure of blockade, and small doses of atropine were as effective as these large doses of guanethidine or phentolamine.3. It is concluded from the blockade of chemical stimulation as well as transmission by these substances that (1) there are only cholinergic fibres innervating eccrine sweat glands, and (2) any inhibitory action by anti-adrenergic substances is due to interaction with cholinergic receptors in the glands.
摘要
- 已经研究了阻断剂对铸型垫和人前臂汗腺反应性的影响。2. 在所检测的抗肾上腺素能物质（双苄胺、苯氧苄胺、溴苄铵、胍乙啶和酚妥拉明）中，只有高剂量的胍乙啶和酚妥拉明产生了任何一致且显著的阻断作用，并且小剂量的阿托品与这些大剂量的胍乙啶或酚妥拉明效果相同。3. 从这些物质对化学刺激以及传递的阻断作用可以得出结论：（1）支配外分泌汗腺的只有胆碱能纤维，（2）抗肾上腺素能物质的任何抑制作用是由于与腺体中的胆碱能受体相互作用所致。
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