猫足垫外泌汗腺对血管内注射儿茶酚胺的反应。
Response of the cat's pad eccrine sweat glands to intravascular injections of catecholamines.
作者信息
Foster K G
出版信息
J Physiol. 1968 Mar;195(2):331-7. doi: 10.1113/jphysiol.1968.sp008461.
Abstract
- Using a sensitive method for detecting and monitoring sweat secretion, a study has been made of the effects of adrenaline and noradrenaline on the cat's pad sweat gland activity in the anaesthetized cat.2. Intravenous or intra-arterial injections of adrenaline or noradrenaline only very occasionally caused these glands to secrete.3. The predominant effect of these drugs on glands which are already secreting in response to plantar nerve stimulation is inhibitory.4. The catecholamine inhibition could be reduced or blocked by phentolamine, but not by propranolol, dibenamine or phenoxybenzamine.5. It is concluded that these glands can be directly activated by intravascular injections of adrenaline or noradrenaline, but that the inhibitory effect of concomitant vasoconstriction usually prevents a response being detected at the skin surface.
摘要
运用一种检测和监测汗液分泌的灵敏方法，对肾上腺素和去甲肾上腺素在麻醉猫的爪垫汗腺活动中的作用进行了研究。
静脉注射或动脉注射肾上腺素或去甲肾上腺素仅偶尔会使这些腺体分泌。
这些药物对因足底神经刺激而已经分泌的腺体的主要作用是抑制性的。
酚妥拉明可降低或阻断儿茶酚胺的抑制作用，但普萘洛尔、双苄胺或苯氧苄胺则不能。
得出的结论是，这些腺体可通过血管内注射肾上腺素或去甲肾上腺素直接激活，但伴随的血管收缩的抑制作用通常会阻止在皮肤表面检测到反应。
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