Negrin P, Fardin P
Riv Neurol. 1979 Jul-Aug;49(4):297-309.
The usefulness of the method of the repetitive stimulation of the peripheral nerves has been widely accepted since the original observations of Desmedt on patients with Myasthenia Gravis, and this test is now routinely performed in many EMG laboratories. On the other hand the technical difficulties and the variability of the results in the various syndromes of neuromuscular fatigability have put some criticism on the value of the test as a routine examination. The AA. make a critical review of the clinical history and of the EMG pattern of 62 patients, who underwent one or more tests of repetitive stimulation during a period of four years, under the suspicion of Myasthenia Gravis or myasthenic syndrome. The AA. give full details of the employed technique and analyze the results either of the 27 cases with Myasthenia Gravis, either of the 15 cases of Myasthenia Gravis with ocular involvement, either of the 16 cases with myasthenic syndrome and of the 4 cases of psychogenic fatigability. The only typical changes of the motor response are its post-tetanic decrease in the not-treated cases of diffuse form of Myasthenia Gravis and its facilitation in the myasthenic syndromes associated with bronchial carcinoma.
自从德斯梅特对重症肌无力患者进行最初观察以来，外周神经重复刺激方法的实用性已被广泛接受，目前许多肌电图实验室都常规进行这项检查。另一方面，在各种神经肌肉疲劳综合征中，该检查存在技术困难且结果存在变异性，这使得人们对该检查作为常规检查的价值提出了一些批评。作者对62例患者的临床病史和肌电图模式进行了批判性回顾，这些患者在四年期间因疑似重症肌无力或肌无力综合征接受了一次或多次重复刺激检查。作者详细介绍了所采用的技术，并分析了27例重症肌无力患者、15例伴有眼部受累的重症肌无力患者、16例肌无力综合征患者以及4例精神性疲劳患者的检查结果。运动反应的唯一典型变化是，在未治疗的弥漫性重症肌无力病例中，强直后反应降低；在与支气管癌相关的肌无力综合征中，强直后反应增强。
