小鼠年龄对皮肤癌发病率的影响。
The effect of the age of mice on the incidence of skin cancer.
作者信息
Lee P N, Peto R
出版信息
Br J Cancer. 1970 Dec;24(4):849-52. doi: 10.1038/bjc.1970.100.
Abstract
The plausibilities of two hypotheses explaining the increased cancer incidence rate in old age caused by a constant dose of carcinogen were compared using a mouse skin painting experiment in which two groups of mice started treatment at different ages. It was shown that the hypothesis of the increased rate being caused simply by increased vulnerability of old animals was not as plausible as the alternative hypothesis of the carcinogen acting to some extent cumulatively.
摘要
通过一项小鼠皮肤涂抹实验比较了两种假说的合理性，这两种假说解释了在给予恒定剂量致癌物的情况下老年期癌症发病率增加的现象。在该实验中，两组小鼠在不同年龄开始接受治疗。结果表明，认为老年动物易感性增加单纯导致发病率上升的假说，不如致癌物在一定程度上具有累积作用的另一种假说合理。
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