小鼠皮肤对香烟烟雾冷凝物的剂量反应研究。
A study of the dose response of mouse skin to cigarette smoke condensate.
作者信息
Davies R F, Lee P N, Rothwell K
出版信息
Br J Cancer. 1974 Aug;30(2):146-56. doi: 10.1038/bjc.1974.126.
Abstract
Smoke condensate from two types of cigarette, dissolved in two solvents, has been applied regularly to the backs of mice at each of seven different dose levels. Treatment was continued 3 times weekly for up to 110 weeks, by which time 509 of the 1428 treated mice had developed skin tumours. The dependence of tumour incidence on age was adequately described by the Weibull distribution. The relation - ship between dose of smoke condensate and tumour incidence rate was, however, erratic. It was less regular than the simple relationship which has in previous work been found to obtain when the pure carcinogen benzo(a)pyrene is applied to mouse skin.
摘要
将两种香烟的烟雾浓缩物溶解于两种溶剂中，以七种不同剂量水平定期涂抹在小鼠背部。每周治疗3次，持续长达110周，到那时，1428只接受治疗的小鼠中有509只患上了皮肤肿瘤。肿瘤发生率与年龄的关系可用威布尔分布充分描述。然而，烟雾浓缩物剂量与肿瘤发生率之间的关系并不稳定。它不如之前将纯致癌物苯并(a)芘涂抹于小鼠皮肤时所发现的简单关系那样规律。
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