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肥厚型心肌病。一项电生理研究。

Hypertrophic cardiomyopathy. An electrophysiological study.

作者信息

Coltart D J, Meldrum S J

出版信息

Br Med J. 1970 Oct 24;4(5729):217-8. doi: 10.1136/bmj.4.5729.217.

DOI:10.1136/bmj.4.5729.217
PMID:5528752
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1819778/
Abstract

Recordings of the transmembrane action potential of the cardiac myofibril from a patient with hypertrophic obstructive cardiomyopathy showed that the repolarization time was appreciably prolonged and that the maximum rate of follow was grossly reduced. This electrical abnormality is compatible with the late and irregular activation of the ventricular muscle in the disease. Propranolol was found to produce a similar "quinidine-like" effect on the transmembrane actionpotential in both cardiomyopathic and control tissue.

摘要

对一名肥厚性梗阻性心肌病患者心肌纤维跨膜动作电位的记录显示，复极化时间明显延长，后续最大速率大幅降低。这种电异常与该疾病中心室肌的延迟和不规则激活相符。发现普萘洛尔对心肌病组织和对照组织的跨膜动作电位产生类似“奎尼丁样”的效应。

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Hypertrophic cardiomyopathy. An electrophysiological study.肥厚型心肌病。一项电生理研究。
Br Med J. 1970 Oct 24;4(5729):217-8. doi: 10.1136/bmj.4.5729.217.
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本文引用的文献

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Antifibrillatory action.抗纤颤作用。
J Physiol. 1962 Mar;160(3):470-82. doi: 10.1113/jphysiol.1962.sp006860.
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DETERMINANTS OF THE DURATION OF THE REFRACTORY PERIOD OF THE ATRIOVENTRICULAR NODAL SYSTEM IN MAN.人类房室结系统不应期持续时间的决定因素
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Operative treatment in idiopathic hypertrophic subaortic stenosis. Techniques, and the results of preoperative and postoperative clinical and hemodynamic assessments.特发性肥厚性主动脉瓣下狭窄的手术治疗。技术以及术前和术后临床与血流动力学评估结果。
Circulation. 1968 Apr;37(4):589-96. doi: 10.1161/01.cir.37.4.589.
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The effect of altered thyroid state on atrial intracellular potentials.甲状腺状态改变对心房细胞内电位的影响。
J Physiol. 1970 Apr;207(2):357-69. doi: 10.1113/jphysiol.1970.sp009066.