肥厚型心肌病。一项电生理研究。
Hypertrophic cardiomyopathy. An electrophysiological study.
作者信息
Coltart D J, Meldrum S J
出版信息
Br Med J. 1970 Oct 24;4(5729):217-8. doi: 10.1136/bmj.4.5729.217.
Abstract
Recordings of the transmembrane action potential of the cardiac myofibril from a patient with hypertrophic obstructive cardiomyopathy showed that the repolarization time was appreciably prolonged and that the maximum rate of follow was grossly reduced. This electrical abnormality is compatible with the late and irregular activation of the ventricular muscle in the disease. Propranolol was found to produce a similar "quinidine-like" effect on the transmembrane actionpotential in both cardiomyopathic and control tissue.
摘要
对一名肥厚性梗阻性心肌病患者心肌纤维跨膜动作电位的记录显示，复极化时间明显延长，后续最大速率大幅降低。这种电异常与该疾病中心室肌的延迟和不规则激活相符。发现普萘洛尔对心肌病组织和对照组织的跨膜动作电位产生类似“奎尼丁样”的效应。
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