博来霉素治疗晚期鳞状细胞癌：一项随机对照试验。医学研究委员会博来霉素工作组报告。
Bleomycin in advanced squamous cell carcinoma: a random controlled trial. Report of Medical Research Council Working Party on Bleomycin.
出版信息
Br Med J. 1976 Jan 24;1(6003):188-90. doi: 10.1136/bmj.1.6003.188.
Abstract
Bleomycin was compared with conventional cytotoxic drugs in the treatment of 70 patients with advanced squamous cell carcinoma; the primary deposit was in the head and neck in 50 patients and in the perineum or skin in 20. Thirty-four patients received bleomycin while 36 received other cytotoxic drugs. No significant difference was detected between the two groups either in the proportion showing tumour regression or in the survival rates. If bleomycin is to advance the treatment of squamous cell carcinoma it can be only in combination with other drugs or with radiotherapy.
摘要
将博来霉素与传统细胞毒性药物用于治疗70例晚期鳞状细胞癌患者进行比较；原发灶位于头颈部的有50例，位于会阴或皮肤的有20例。34例患者接受博来霉素治疗，36例接受其他细胞毒性药物治疗。两组在肿瘤消退比例或生存率方面均未检测到显著差异。如果博来霉素要推进鳞状细胞癌的治疗，只能与其他药物联合使用或与放疗联合使用。
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