Kutscher C L, Yamamoto B K
Neurobehav Toxicol. 1979 Winter;1(4):259-62.
Procedural variables are crucial in using taste aversion as a measure of lead toxicity. Rats were given saccharin and water to drink while ingesting a diet containing lead acetate (PbAc). Rats showed high preference for saccharin (over water) before lead was introduced. Saccharian preference fell during PbAc ingestion and rose when PbAc was removed from the diet suggesting that saccharin preference may correlate with the physiologic action of the toxicant. When saccharin was introduced simultaneously with PbAc aversion was almost total, but recovered with continuous PbAc exposure. When saccharin was introduced after the start of PbAc exposure saccharin aversion diminished with the duration of presaccharin PbAc exposure.
在将味觉厌恶作为铅毒性的一种测量方法时，程序变量至关重要。给大鼠喂食含醋酸铅（PbAc）的食物时，让它们饮用糖精和水。在引入铅之前，大鼠对糖精（相对于水）表现出高度偏好。在摄入PbAc期间，糖精偏好下降，而当从饮食中去除PbAc时，糖精偏好上升，这表明糖精偏好可能与毒物的生理作用相关。当糖精与PbAc同时引入时，厌恶几乎是完全的，但随着持续接触PbAc而恢复。当在开始接触PbAc后引入糖精时，糖精厌恶随着接触PbAc的时间延长而减弱。
