Ganesan R, Rosellini R A, Svare B
Department of Psychology, State University of New York, Albany.
Appetite. 1993 Feb;20(1):1-11. doi: 10.1006/appe.1993.1001.
The aversive effects of estradiol have been studied in two different taste aversion paradigms. A similar investigation was undertaken for the anabolic-androgenic steroids, nandralone and testosterone cypionate, using Rockland-Swiss mice. Experiments 1 and 2 used the brief exposure of a novel saccharin solution as the conditioned stimulus for taste aversion learning, and showed that anabolic steroids (1 mg) do not induce taste aversions. Instead, these hormones induced a small non-contingent increase in saccharin preference. Experiment 3 showed that daily nandralone administration (1 mg/day) had a greater anabolic effect than the same dose of testosterone cypionate. Experiment 4 paired the continuous exposure to a novel diet with daily nandralone injections, and showed that steroid treatment increased intake of the novel diet. When the novel diet was subsequently presented with the familiar diet in a two-choice preference test, there was no indication that an aversion was conditioned to the novel target diet. On the contrary, nandralone treatment significantly increased the preference for the novel diet. These experiments show that anabolic-androgenic steroids do not have aversive effects in mice, and that they may have positive consequences.
已在两种不同的味觉厌恶范式中研究了雌二醇的厌恶作用。使用罗克兰-瑞士小鼠对合成代谢雄激素类固醇诺龙和环戊丙酸睾酮进行了类似的研究。实验1和实验2使用短暂接触一种新型糖精溶液作为味觉厌恶学习的条件刺激，结果表明合成代谢类固醇（1毫克）不会诱发味觉厌恶。相反，这些激素使糖精偏好出现了少量非偶然的增加。实验3表明，每日给予诺龙（1毫克/天）比给予相同剂量的环戊丙酸睾酮具有更强的合成代谢作用。实验4将持续接触一种新型饮食与每日注射诺龙相结合，结果表明类固醇治疗增加了新型饮食的摄入量。当随后在二选一偏好测试中将新型饮食与熟悉的饮食一起呈现时，没有迹象表明对新型目标饮食形成了厌恶。相反，诺龙治疗显著增加了对新型饮食的偏好。这些实验表明，合成代谢雄激素类固醇在小鼠中没有厌恶作用，而且可能会产生积极的影响。
